Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate

Susan M. Carlton, Helena A. Lekan, Sun Ho Kim, Jin Chung

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

A goal of the present study was to document the behavioral changes observed in a model of painful neuropathy in the primate (Macaca fascicularis). A neuropathic state was induced by tight ligation of the L7 spinal nerve, just distal to the L7 dorsal root ganglion. Sensory testing was done on the ventral surface of the foot, a region that includes the L7 dermatome. Within 1 week following surgery, all monkeys (n = 3) developed a marked sensitivity to mechanical stimulation (with a camel hair brush and von Frey hairs), indicating the presence of mechanical allodynia. In 2 animals, the increased sensitivity to mechanical stimulation was also observed on the contralateral side. The threshold for withdrawal to a heat stimulus decreased, indicating the presence of heat hyperalgesia. Presentation of various cooling stimuli, such as acetone and cold water baths, suggested that cold allodynia had also developed. These behavioral phenomena are similar to those seen in humans diagnosed with peripheral neuropathic pain. The behavioral abnormalities are discussed in relation to the responses of spinothalamic tract cells recorded from primates with the same peripheral nerve injury (Palecek et al. 1992).

Original languageEnglish (US)
Pages (from-to)155-166
Number of pages12
JournalPain
Volume56
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Spinal Nerves
Hyperalgesia
Peripheral Nervous System Diseases
Primates
Ligation
Theoretical Models
Hair
Spinothalamic Tracts
Hot Temperature
Peripheral Nerve Injuries
Camelus
Macaca fascicularis
Spinal Ganglia
Neuralgia
Acetone
Baths
Haplorhini
Foot
Water

Keywords

  • Allodynia
  • Causalgia
  • Hyperalgesia
  • Peripheral nerve injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neurology
  • Pharmacology
  • Clinical Psychology

Cite this

Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate. / Carlton, Susan M.; Lekan, Helena A.; Kim, Sun Ho; Chung, Jin.

In: Pain, Vol. 56, No. 2, 1994, p. 155-166.

Research output: Contribution to journalArticle

Carlton, Susan M. ; Lekan, Helena A. ; Kim, Sun Ho ; Chung, Jin. / Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate. In: Pain. 1994 ; Vol. 56, No. 2. pp. 155-166.
@article{77101b807a394f3cb5e0aa214612333e,
title = "Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate",
abstract = "A goal of the present study was to document the behavioral changes observed in a model of painful neuropathy in the primate (Macaca fascicularis). A neuropathic state was induced by tight ligation of the L7 spinal nerve, just distal to the L7 dorsal root ganglion. Sensory testing was done on the ventral surface of the foot, a region that includes the L7 dermatome. Within 1 week following surgery, all monkeys (n = 3) developed a marked sensitivity to mechanical stimulation (with a camel hair brush and von Frey hairs), indicating the presence of mechanical allodynia. In 2 animals, the increased sensitivity to mechanical stimulation was also observed on the contralateral side. The threshold for withdrawal to a heat stimulus decreased, indicating the presence of heat hyperalgesia. Presentation of various cooling stimuli, such as acetone and cold water baths, suggested that cold allodynia had also developed. These behavioral phenomena are similar to those seen in humans diagnosed with peripheral neuropathic pain. The behavioral abnormalities are discussed in relation to the responses of spinothalamic tract cells recorded from primates with the same peripheral nerve injury (Palecek et al. 1992).",
keywords = "Allodynia, Causalgia, Hyperalgesia, Peripheral nerve injury",
author = "Carlton, {Susan M.} and Lekan, {Helena A.} and Kim, {Sun Ho} and Jin Chung",
year = "1994",
doi = "10.1016/0304-3959(94)90090-6",
language = "English (US)",
volume = "56",
pages = "155--166",
journal = "Pain",
issn = "0304-3959",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate

AU - Carlton, Susan M.

AU - Lekan, Helena A.

AU - Kim, Sun Ho

AU - Chung, Jin

PY - 1994

Y1 - 1994

N2 - A goal of the present study was to document the behavioral changes observed in a model of painful neuropathy in the primate (Macaca fascicularis). A neuropathic state was induced by tight ligation of the L7 spinal nerve, just distal to the L7 dorsal root ganglion. Sensory testing was done on the ventral surface of the foot, a region that includes the L7 dermatome. Within 1 week following surgery, all monkeys (n = 3) developed a marked sensitivity to mechanical stimulation (with a camel hair brush and von Frey hairs), indicating the presence of mechanical allodynia. In 2 animals, the increased sensitivity to mechanical stimulation was also observed on the contralateral side. The threshold for withdrawal to a heat stimulus decreased, indicating the presence of heat hyperalgesia. Presentation of various cooling stimuli, such as acetone and cold water baths, suggested that cold allodynia had also developed. These behavioral phenomena are similar to those seen in humans diagnosed with peripheral neuropathic pain. The behavioral abnormalities are discussed in relation to the responses of spinothalamic tract cells recorded from primates with the same peripheral nerve injury (Palecek et al. 1992).

AB - A goal of the present study was to document the behavioral changes observed in a model of painful neuropathy in the primate (Macaca fascicularis). A neuropathic state was induced by tight ligation of the L7 spinal nerve, just distal to the L7 dorsal root ganglion. Sensory testing was done on the ventral surface of the foot, a region that includes the L7 dermatome. Within 1 week following surgery, all monkeys (n = 3) developed a marked sensitivity to mechanical stimulation (with a camel hair brush and von Frey hairs), indicating the presence of mechanical allodynia. In 2 animals, the increased sensitivity to mechanical stimulation was also observed on the contralateral side. The threshold for withdrawal to a heat stimulus decreased, indicating the presence of heat hyperalgesia. Presentation of various cooling stimuli, such as acetone and cold water baths, suggested that cold allodynia had also developed. These behavioral phenomena are similar to those seen in humans diagnosed with peripheral neuropathic pain. The behavioral abnormalities are discussed in relation to the responses of spinothalamic tract cells recorded from primates with the same peripheral nerve injury (Palecek et al. 1992).

KW - Allodynia

KW - Causalgia

KW - Hyperalgesia

KW - Peripheral nerve injury

UR - http://www.scopus.com/inward/record.url?scp=0028058081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028058081&partnerID=8YFLogxK

U2 - 10.1016/0304-3959(94)90090-6

DO - 10.1016/0304-3959(94)90090-6

M3 - Article

C2 - 8008406

AN - SCOPUS:0028058081

VL - 56

SP - 155

EP - 166

JO - Pain

JF - Pain

SN - 0304-3959

IS - 2

ER -