Beneficial effects of extended growth hormone treatment after hospital discharge in pediatric burn patients

Rene Przkora, David Herndon, Oscar Suman, Marc G. Jeschke, Walter Meyer, David L. Chinkes, Ronald P. Mlcak, Ted Huang, Robert E. Barrow

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

OBJECTIVE: To study the efficacy of growth hormone given to severely burned children from discharge to 12 months after burn and for 12 months after the drug was discontinued. SUMMARY BACKGROUND DATA: We have previously shown that low-dose recombinant human growth hormone (rhGH), given to children after a severe thermal injury, successfully improved lean muscle mass, bone mineral content, and growth. The aim of the present study was to investigate long-term functional improvements after treatment. METHODS: Forty-four pediatric patients with over 40% total body surface area burns were studied for 24 months after burn. Patients were randomized to receive either rhGH (0.05 mg/kg body weight) or placebo. Height, weight, body composition, serum hormones, resting energy expenditure, cardiac function, muscle strength, and number of reconstructive procedures performed were measured during rhGH treatment and for 12 months after treatment was discontinued. Statistical analysis used Tukey's multiple comparison test. Significance was accepted at P < 0.05. RESULTS: Height, weight, lean body mass, bone mineral content, cardiac function, and muscle strength significantly improved during rhGH treatment compared with placebo (P < 0.05). This treatment significantly increased GH, IGF-I, and IGFBP-3, whereas serum cortisol decreased (P < 0.05). The number of operative reconstructive procedures was significantly lower with rhGH (P < 0.05). Improvements in height, bone mineral content, and IGF-1 concentrations persisted after rhGH treatment (P < 0.05). No side effects with rhGH were observed. CONCLUSIONS: Administration of rhGH for 1 year after burn was safe and improved recovery. These salutary effects continued after rhGH treatment was discontinued.

Original languageEnglish (US)
Pages (from-to)796-801
Number of pages6
JournalAnnals of Surgery
Volume243
Issue number6
DOIs
StatePublished - Jun 2006

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Human Growth Hormone
Growth Hormone
Pediatrics
Bone Density
Therapeutics
Muscle Strength
Insulin-Like Growth Factor I
Myocardium
Placebos
Body Weight
Insulin-Like Growth Factor Binding Protein 3
Body Surface Area
Operative Surgical Procedures
Body Composition
Serum
Burns
Energy Metabolism
Hydrocortisone
Hot Temperature
Hormones

ASJC Scopus subject areas

  • Surgery

Cite this

Beneficial effects of extended growth hormone treatment after hospital discharge in pediatric burn patients. / Przkora, Rene; Herndon, David; Suman, Oscar; Jeschke, Marc G.; Meyer, Walter; Chinkes, David L.; Mlcak, Ronald P.; Huang, Ted; Barrow, Robert E.

In: Annals of Surgery, Vol. 243, No. 6, 06.2006, p. 796-801.

Research output: Contribution to journalArticle

Przkora, R, Herndon, D, Suman, O, Jeschke, MG, Meyer, W, Chinkes, DL, Mlcak, RP, Huang, T & Barrow, RE 2006, 'Beneficial effects of extended growth hormone treatment after hospital discharge in pediatric burn patients', Annals of Surgery, vol. 243, no. 6, pp. 796-801. https://doi.org/10.1097/01.sla.0000219676.69331.fd
Przkora, Rene ; Herndon, David ; Suman, Oscar ; Jeschke, Marc G. ; Meyer, Walter ; Chinkes, David L. ; Mlcak, Ronald P. ; Huang, Ted ; Barrow, Robert E. / Beneficial effects of extended growth hormone treatment after hospital discharge in pediatric burn patients. In: Annals of Surgery. 2006 ; Vol. 243, No. 6. pp. 796-801.
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AU - Meyer, Walter

AU - Chinkes, David L.

AU - Mlcak, Ronald P.

AU - Huang, Ted

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