Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: Lessons learned from experimental and clinical studies

Robert G. Kilbourn, Csaba Szabo, Daniel L. Traber

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Septic shock is a physiological derangement of the cardiovascular system characterized by pathological vasodilation. Recent studies have established a role for nitric oxide, previously known as endothelium-derived relaxing factor, in the vascular dysfunction of sepsis. This finding suggests that inhibition of nitric oxide synthase (NOS), the enzyme responsible for nitric oxide production, could be a target for therapeutic intervention. Animal studies have provided conflicting results, demonstrating both beneficial and detrimental effects. We provide here an overview of the preclinical studies of NOS inhibitors and an update of the clinical studies. The low toxicity and marked antihypotensive activity of NOS inhibitors in humans highlight some of the drawbacks of certain animal models and provide important insights into the experimental study of septic shock.

Original languageEnglish (US)
Pages (from-to)235-246
Number of pages12
JournalShock
Volume7
Issue number4
StatePublished - 1997
Externally publishedYes

Fingerprint

Nitric Oxide Synthase
Shock
Septic Shock
Nitric Oxide
Endothelium-Dependent Relaxing Factors
Cardiovascular System
Vasodilation
Blood Vessels
Sepsis
Animal Models
Enzymes
Clinical Studies
Therapeutics

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Physiology

Cite this

Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock : Lessons learned from experimental and clinical studies. / Kilbourn, Robert G.; Szabo, Csaba; Traber, Daniel L.

In: Shock, Vol. 7, No. 4, 1997, p. 235-246.

Research output: Contribution to journalArticle

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