Benefits of high-dose dopamine in experimental neonatal septic shock

T. E. Lobe, R. Paone, S. R. Dent, P. Mancillas, M. B. Smith, J. G. Hilton, David Herndon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The benefits of dopamine resuscitation in neonatal shock are in doubt. To evaluate dopamine's effectiveness on regional perfusion and survival, neonatal pigs were subjected to fecal Escherichia coli peritonitis-induced septic shock and were randomly divided into equal groups. Control animals (Group I) were not resuscitated with dopamine. Dopamine resuscitation, as a continuous infusion of 5 μg/kg/min (Group II), 50 μg/kg/min (Group III), or 200 μg/kg/min (Group IV), began when cardiac output dropped 20% below baseline. Radiolabeled microspheres were used to assess regional perfusion. Survival was defined as no hemodynamic compromise at 24 hr. Increased survival time correlated with sustained increases in cardiac output and blood pressure in Group III, which were not observed in the other groups. Significant changes in multiorgan regional perfusion were also observed in Group III and correlate with the improved survival. These data suggest that higher than usual doses of dopamine may be beneficial in neonates with peritonitis-induced septic shock.

Original languageEnglish (US)
Pages (from-to)665-674
Number of pages10
JournalJournal of Surgical Research
Volume42
Issue number6
DOIs
StatePublished - 1987

Fingerprint

Septic Shock
Dopamine
Perfusion
Peritonitis
Resuscitation
Cardiac Output
Microspheres
Shock
Swine
Hemodynamics
Escherichia coli
Blood Pressure
Control Groups

ASJC Scopus subject areas

  • Surgery

Cite this

Lobe, T. E., Paone, R., Dent, S. R., Mancillas, P., Smith, M. B., Hilton, J. G., & Herndon, D. (1987). Benefits of high-dose dopamine in experimental neonatal septic shock. Journal of Surgical Research, 42(6), 665-674. https://doi.org/10.1016/0022-4804(87)90011-4

Benefits of high-dose dopamine in experimental neonatal septic shock. / Lobe, T. E.; Paone, R.; Dent, S. R.; Mancillas, P.; Smith, M. B.; Hilton, J. G.; Herndon, David.

In: Journal of Surgical Research, Vol. 42, No. 6, 1987, p. 665-674.

Research output: Contribution to journalArticle

Lobe, TE, Paone, R, Dent, SR, Mancillas, P, Smith, MB, Hilton, JG & Herndon, D 1987, 'Benefits of high-dose dopamine in experimental neonatal septic shock', Journal of Surgical Research, vol. 42, no. 6, pp. 665-674. https://doi.org/10.1016/0022-4804(87)90011-4
Lobe, T. E. ; Paone, R. ; Dent, S. R. ; Mancillas, P. ; Smith, M. B. ; Hilton, J. G. ; Herndon, David. / Benefits of high-dose dopamine in experimental neonatal septic shock. In: Journal of Surgical Research. 1987 ; Vol. 42, No. 6. pp. 665-674.
@article{ae77f578980a40f8a927c1a3798bf5d8,
title = "Benefits of high-dose dopamine in experimental neonatal septic shock",
abstract = "The benefits of dopamine resuscitation in neonatal shock are in doubt. To evaluate dopamine's effectiveness on regional perfusion and survival, neonatal pigs were subjected to fecal Escherichia coli peritonitis-induced septic shock and were randomly divided into equal groups. Control animals (Group I) were not resuscitated with dopamine. Dopamine resuscitation, as a continuous infusion of 5 μg/kg/min (Group II), 50 μg/kg/min (Group III), or 200 μg/kg/min (Group IV), began when cardiac output dropped 20{\%} below baseline. Radiolabeled microspheres were used to assess regional perfusion. Survival was defined as no hemodynamic compromise at 24 hr. Increased survival time correlated with sustained increases in cardiac output and blood pressure in Group III, which were not observed in the other groups. Significant changes in multiorgan regional perfusion were also observed in Group III and correlate with the improved survival. These data suggest that higher than usual doses of dopamine may be beneficial in neonates with peritonitis-induced septic shock.",
author = "Lobe, {T. E.} and R. Paone and Dent, {S. R.} and P. Mancillas and Smith, {M. B.} and Hilton, {J. G.} and David Herndon",
year = "1987",
doi = "10.1016/0022-4804(87)90011-4",
language = "English (US)",
volume = "42",
pages = "665--674",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "6",

}

TY - JOUR

T1 - Benefits of high-dose dopamine in experimental neonatal septic shock

AU - Lobe, T. E.

AU - Paone, R.

AU - Dent, S. R.

AU - Mancillas, P.

AU - Smith, M. B.

AU - Hilton, J. G.

AU - Herndon, David

PY - 1987

Y1 - 1987

N2 - The benefits of dopamine resuscitation in neonatal shock are in doubt. To evaluate dopamine's effectiveness on regional perfusion and survival, neonatal pigs were subjected to fecal Escherichia coli peritonitis-induced septic shock and were randomly divided into equal groups. Control animals (Group I) were not resuscitated with dopamine. Dopamine resuscitation, as a continuous infusion of 5 μg/kg/min (Group II), 50 μg/kg/min (Group III), or 200 μg/kg/min (Group IV), began when cardiac output dropped 20% below baseline. Radiolabeled microspheres were used to assess regional perfusion. Survival was defined as no hemodynamic compromise at 24 hr. Increased survival time correlated with sustained increases in cardiac output and blood pressure in Group III, which were not observed in the other groups. Significant changes in multiorgan regional perfusion were also observed in Group III and correlate with the improved survival. These data suggest that higher than usual doses of dopamine may be beneficial in neonates with peritonitis-induced septic shock.

AB - The benefits of dopamine resuscitation in neonatal shock are in doubt. To evaluate dopamine's effectiveness on regional perfusion and survival, neonatal pigs were subjected to fecal Escherichia coli peritonitis-induced septic shock and were randomly divided into equal groups. Control animals (Group I) were not resuscitated with dopamine. Dopamine resuscitation, as a continuous infusion of 5 μg/kg/min (Group II), 50 μg/kg/min (Group III), or 200 μg/kg/min (Group IV), began when cardiac output dropped 20% below baseline. Radiolabeled microspheres were used to assess regional perfusion. Survival was defined as no hemodynamic compromise at 24 hr. Increased survival time correlated with sustained increases in cardiac output and blood pressure in Group III, which were not observed in the other groups. Significant changes in multiorgan regional perfusion were also observed in Group III and correlate with the improved survival. These data suggest that higher than usual doses of dopamine may be beneficial in neonates with peritonitis-induced septic shock.

UR - http://www.scopus.com/inward/record.url?scp=0023223343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023223343&partnerID=8YFLogxK

U2 - 10.1016/0022-4804(87)90011-4

DO - 10.1016/0022-4804(87)90011-4

M3 - Article

VL - 42

SP - 665

EP - 674

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 6

ER -