Benzene myeloclastogenicity

A function of its metabolism

M. M. Gad-El-Karim, V-M Ramanujam, A. E. Ahmed, M. S. Legator

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Using the micronucleus test we have found no significant difference between germ-free and conventional (non-germ-free) male CD-1 mice gavaged twice with 440 or 880 mg benzene/kg. Hence, the higher myeloclastogenicity observed previously with the p.o. (4-6 times) than with the i.p. route of benzene administration was ruled out as being due to the involvement of gut flora in benzene biotransformation. Pretreatment of males with 3-methylcholanthrene or β-naphthoflavone, inducers of P-448 monooxygenase, but not phenobarbital, an inducer of P-450, significantly enhanced the myeloclastogenic effect of a single oral dose of benzene (440 mg/kg). Single oral doses of phenol, catechol, or hydroquinone (250, 150, and 200 mg/kg, respectively) failed to reproduce the potent myeloclastogenic effect of benzene. In fact, only hydroquinone was mildly clastogenic. The relation between benzene's myeloclastogenicity and metabolism is discussed.

Original languageEnglish (US)
Pages (from-to)475-484
Number of pages10
JournalAmerican Journal of Industrial Medicine
Volume7
Issue number5-6
StatePublished - 1985

Fingerprint

Benzene
Micronucleus Tests
Methylcholanthrene
Phenobarbital
Biotransformation
Mixed Function Oxygenases
Phenol

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Gad-El-Karim, M. M., Ramanujam, V-M., Ahmed, A. E., & Legator, M. S. (1985). Benzene myeloclastogenicity: A function of its metabolism. American Journal of Industrial Medicine, 7(5-6), 475-484.

Benzene myeloclastogenicity : A function of its metabolism. / Gad-El-Karim, M. M.; Ramanujam, V-M; Ahmed, A. E.; Legator, M. S.

In: American Journal of Industrial Medicine, Vol. 7, No. 5-6, 1985, p. 475-484.

Research output: Contribution to journalArticle

Gad-El-Karim, MM, Ramanujam, V-M, Ahmed, AE & Legator, MS 1985, 'Benzene myeloclastogenicity: A function of its metabolism', American Journal of Industrial Medicine, vol. 7, no. 5-6, pp. 475-484.
Gad-El-Karim, M. M. ; Ramanujam, V-M ; Ahmed, A. E. ; Legator, M. S. / Benzene myeloclastogenicity : A function of its metabolism. In: American Journal of Industrial Medicine. 1985 ; Vol. 7, No. 5-6. pp. 475-484.
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