Beta-amyloid peptide - Nicotinic acetylcholine receptor interaction: The two faces of health and disease

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Elevated amyloid-beta peptide (Abeta) and loss of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery of an Abeta - nAChR interaction, much effort has been expended to understand how this interaction may contribute to normal physiological processes as well as AD. Several researchers have expanded on the initial observation of an Abeta-nAChR interaction to characterize the pertinent factors that confer Abeta sensitivity to nAChRs. Some of which include the following: 1. receptor subunit composition; 2. receptor subunit stoichiometry; 3. regional distribution; 4. presynaptic versus somatic distribution; 5. neuron versus glia expression; 6. in vitro expression system. These aspects of nAChR composition and expression appear to confer the specific functional consequences of Abeta interaction which range from blockade of receptor activation to stimulation of second messenger cascades that provide neuroprotection from Abeta toxicity. This review will discuss the extant literature on the subject in terms of clarifying this apparent dichotomy regarding the consequences of Abeta - nAChR interaction during health and disease.

Original languageEnglish (US)
Pages (from-to)5030-5038
Number of pages9
JournalFrontiers in Bioscience
Volume12
Issue number13
DOIs
StatePublished - Sep 1 2007

Fingerprint

Amyloid beta-Peptides
Nicotinic Receptors
Health
Alzheimer Disease
Physiological Phenomena
Second Messenger Systems
Chemical analysis
Neuroglia
Stoichiometry
Neurons
Toxicity
Chemical activation
Research Personnel
Observation

Keywords

  • Alpha7
  • Alzheimer's disease
  • Amyloid
  • Cholinergic
  • Neuroprotection
  • Nicotinic
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Beta-amyloid peptide - Nicotinic acetylcholine receptor interaction : The two faces of health and disease. / Dineley, Kelly.

In: Frontiers in Bioscience, Vol. 12, No. 13, 01.09.2007, p. 5030-5038.

Research output: Contribution to journalArticle

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