Beta endorphin, a vasoconstrictor during septic shock

S. Doty, L. Traber, David Herndon, R. Kimura, H. Lubbesmeyer, S. Davenport, D. Traber

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A relationship between increased peripheral resistance (TPRI) and decreased cardiac index (CI) and mortality from sepsis has been suggested. The relationship between endogenous opiates and this response was evaluated. Methods: Chronically instrumented sheep were given E. coli endotoxin (LPS, 1.5 mcg/kg x 30 minutes). In one study, survivors (n = 9) and nonsurvivors (n = 11) of LPS were compared along with survivors (n = 8) of half the dose of LPS. In a second study, two groups of animals received naloxone: one (n = 11) had a bolus of 2 mg/kg followed by a 2 mg/kg/hr continuous infusion started 30 minutes before LPS while the other had the bolus and infusion started 1 hour after LPS was begun. Results: Both vasoconstrictive and vasodilative phases were seen. Vasoconstriction was associated with elevated beta endorphin levels, a pattern sustained until death in the nonsurvivors. Both pre- and post-treatment with naloxone lessened the maximum increase in total peripheral resistance index compared with untreated sheep. Discussion: The vasoconstrictive aspects of the response to LPS correlated with elevated beta endorphin levels and with mortality. This vascular response is attenuated with naloxone blockade.

Original languageEnglish (US)
Pages (from-to)131-139
Number of pages9
JournalJournal of Trauma
Volume28
Issue number2
StatePublished - 1988

Fingerprint

beta-Endorphin
Vasoconstrictor Agents
Septic Shock
Naloxone
Vascular Resistance
Survivors
Sheep
Opioid Peptides
Mortality
Vasoconstriction
Endotoxins
Blood Vessels
Sepsis
Escherichia coli
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Doty, S., Traber, L., Herndon, D., Kimura, R., Lubbesmeyer, H., Davenport, S., & Traber, D. (1988). Beta endorphin, a vasoconstrictor during septic shock. Journal of Trauma, 28(2), 131-139.

Beta endorphin, a vasoconstrictor during septic shock. / Doty, S.; Traber, L.; Herndon, David; Kimura, R.; Lubbesmeyer, H.; Davenport, S.; Traber, D.

In: Journal of Trauma, Vol. 28, No. 2, 1988, p. 131-139.

Research output: Contribution to journalArticle

Doty, S, Traber, L, Herndon, D, Kimura, R, Lubbesmeyer, H, Davenport, S & Traber, D 1988, 'Beta endorphin, a vasoconstrictor during septic shock', Journal of Trauma, vol. 28, no. 2, pp. 131-139.
Doty S, Traber L, Herndon D, Kimura R, Lubbesmeyer H, Davenport S et al. Beta endorphin, a vasoconstrictor during septic shock. Journal of Trauma. 1988;28(2):131-139.
Doty, S. ; Traber, L. ; Herndon, David ; Kimura, R. ; Lubbesmeyer, H. ; Davenport, S. ; Traber, D. / Beta endorphin, a vasoconstrictor during septic shock. In: Journal of Trauma. 1988 ; Vol. 28, No. 2. pp. 131-139.
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