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Beta-secretase: Structure, function, and evolution
Chitra Venugopal
, Christina M. Demos
, K. S. Jagannatha Rao
,
Miguel A. Pappolla
, Kumar Sambamurti
Research output
:
Contribution to journal
›
Review article
›
peer-review
116
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Scopus citations
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Dive into the research topics of 'Beta-secretase: Structure, function, and evolution'. Together they form a unique fingerprint.
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Keyphrases
Structure Evolution
100%
β-site APP-cleaving Enzyme 1 (BACE1)
100%
Alzheimer's Disease
22%
Drug Target
22%
Secretase
22%
Knock-in Mouse Model
11%
Novel Mechanism
11%
Drug-like
11%
Transmembrane
11%
Brain Penetrant
11%
Biological Properties
11%
Amyloid-β Peptide
11%
Popular
11%
Novel Class
11%
Phylogenetic Perspective
11%
Memapsin 2
11%
Protein Precursors
11%
Incomplete Understanding
11%
Catalytic Pocket
11%
Aspartic Protease
11%
Immunology and Microbiology
Precursor
100%
Knockout Mouse
100%
Peptides
100%
Biochemistry, Genetics and Molecular Biology
Secretase
100%
Knockout Mouse
33%
Protein Precursor
33%
Protease
33%
Amyloid Protein
33%
Pharmacology, Toxicology and Pharmaceutical Science
Beta Secretase
100%
Alzheimer's Disease
18%
Secretase
18%
Knockout Mouse
9%
Aspartic Proteinase
9%
Protein Precursor
9%
Amyloid Protein
9%
Neuroscience
Beta Secretase
100%
Alzheimer's Disease
18%
Secretase
18%
Protein Precursor
9%
Amyloid Protein
9%
Aspartic Proteinase
9%
Chemistry
Drug Target
100%
Biological Property
50%