Better Safe than Sorry: A Dual-Function Viral Protein Inhibiting Host Defense

Bernhard C. Lechtenberg, Andrew Routh

Research output: Contribution to journalShort survey

Abstract

Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation. Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation.

Original languageEnglish (US)
Pages (from-to)467-469
Number of pages3
JournalCell Host and Microbe
Volume24
Issue number4
DOIs
StatePublished - Oct 10 2018

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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