Better Safe than Sorry: A Dual-Function Viral Protein Inhibiting Host Defense

Bernhard C. Lechtenberg; Andrew Routh

doi:10.1016/j.chom.2018.09.012

Better Safe than Sorry: A Dual-Function Viral Protein Inhibiting Host Defense

Bernhard C. Lechtenberg
, Andrew Routh

Biochemistry & Molecular Biology

Research output: Contribution to journal › Short survey › peer-review

Abstract

Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation. Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation.

Original language	English (US)
Pages (from-to)	467-469
Number of pages	3
Journal	Cell Host and Microbe
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2018.09.012
State	Published - Oct 10 2018

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2018.09.012

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title = "Better Safe than Sorry: A Dual-Function Viral Protein Inhibiting Host Defense",

abstract = "Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host \& Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation. Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host \& Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation.",

author = "Lechtenberg, \{Bernhard C.\} and Andrew Routh",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

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doi = "10.1016/j.chom.2018.09.012",

language = "English (US)",

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T1 - Better Safe than Sorry

T2 - A Dual-Function Viral Protein Inhibiting Host Defense

AU - Lechtenberg, Bernhard C.

AU - Routh, Andrew

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Y1 - 2018/10/10

N2 - Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation. Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation.

AB - Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation. Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation.

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UR - https://www.scopus.com/pages/publications/85054003648#tab=citedBy

U2 - 10.1016/j.chom.2018.09.012

DO - 10.1016/j.chom.2018.09.012

M3 - Short survey

C2 - 30308151

AN - SCOPUS:85054003648

SN - 1931-3128

VL - 24

SP - 467

EP - 469

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 4

ER -

Better Safe than Sorry: A Dual-Function Viral Protein Inhibiting Host Defense

Abstract

ASJC Scopus subject areas

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