TY - JOUR
T1 - Beyond Borders
T2 - Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in Brazil
AU - Saivish, Marielena V.
AU - Nogueira, Maurício L.
AU - Rossi, Shannan
AU - Vasilakis, Nikos
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/2/22
Y1 - 2024/2/22
N2 - Cacipacoré virus (CPCV) was discovered in 1977 deep in the Amazon rainforest from the blood of a black-faced ant thrush (Formicarius analis). As a member of the family Flaviviridae and genus orthoflavivirus, CPCV’s intricate ecological association with vectors and hosts raises profound questions. CPCV’s transmission cycle may involve birds, rodents, equids, bovines, marsupials, non-human primates, and bats as potential vertebrate hosts, whereas Culex and Aedes spp. mosquitoes have been implicated as potential vectors of transmission. The virus’ isolation across diverse biomes, including urban settings, suggests its adaptability, as well as presents challenges for its accurate diagnosis, and thus its impact on veterinary and human health. With no specific treatment or vaccine, its prevention hinges on traditional arbovirus control measures. Here, we provide an overview of its ecology, transmission cycles, epidemiology, pathogenesis, and prevention, aiming at improving our ability to better understand this neglected arbovirus.
AB - Cacipacoré virus (CPCV) was discovered in 1977 deep in the Amazon rainforest from the blood of a black-faced ant thrush (Formicarius analis). As a member of the family Flaviviridae and genus orthoflavivirus, CPCV’s intricate ecological association with vectors and hosts raises profound questions. CPCV’s transmission cycle may involve birds, rodents, equids, bovines, marsupials, non-human primates, and bats as potential vertebrate hosts, whereas Culex and Aedes spp. mosquitoes have been implicated as potential vectors of transmission. The virus’ isolation across diverse biomes, including urban settings, suggests its adaptability, as well as presents challenges for its accurate diagnosis, and thus its impact on veterinary and human health. With no specific treatment or vaccine, its prevention hinges on traditional arbovirus control measures. Here, we provide an overview of its ecology, transmission cycles, epidemiology, pathogenesis, and prevention, aiming at improving our ability to better understand this neglected arbovirus.
KW - clinical manifestations
KW - epidemiology
KW - Orthoflavivirus
KW - pathogenesis
KW - transmission cycles
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U2 - 10.3390/v16030336
DO - 10.3390/v16030336
M3 - Article
C2 - 38543701
AN - SCOPUS:85189257235
SN - 1999-4915
VL - 16
JO - Viruses
JF - Viruses
IS - 3
M1 - 336
ER -