Bilateral entry and release of middle east respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells

Xinrong Tao, Terence E. Hill, Chikao Morimoto, Clarence J. Peters, Thomas Ksiazek, Chien-Te Tseng

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.

Original languageEnglish (US)
Pages (from-to)9953-9958
Number of pages6
JournalJournal of Virology
Volume87
Issue number17
DOIs
StatePublished - 2013

Fingerprint

Severe Acute Respiratory Syndrome
epithelial cells
apoptosis
Epithelial Cells
Apoptosis
viruses
Viruses
pathogenesis
cells
infection
Infection
Middle East Respiratory Syndrome Coronavirus
Middle East respiratory syndrome coronavirus

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Bilateral entry and release of middle east respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells. / Tao, Xinrong; Hill, Terence E.; Morimoto, Chikao; Peters, Clarence J.; Ksiazek, Thomas; Tseng, Chien-Te.

In: Journal of Virology, Vol. 87, No. 17, 2013, p. 9953-9958.

Research output: Contribution to journalArticle

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