Biliary endogenous inorganic phosphate, D-glucose, IgA and transferrin are differentially altered by hydrostatic pressure

Mary Treinen Moslen, Mary F. Kanz, Jatinder Bhatia, Lata Kaphalia, Randall M. Goldblum

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Our objective was to determine the effects of hydrostatic biliary pressure on excretion patterns of endogenous solutes which reflect various pathways of bile formation. A stable in vivo model was developed using anesthetized rats intraduodenally infused with taurocholate to maintain bile flow. Bile was collected during a 2-h basal period, a 4-h pressure period where elevation of the bile duct cannula decreased bile flow to 1/3 the basal rate, and a 2-h period after release of hydrostatic biliary pressure. During pressure treatment, bile salt concentration gradually increased ∼3-fold, biliary inorganic phosphate concentrations rapidly rost ∼5-fold, and biliary glucose concentration progressively rose ∼17-fold. Concentrations of proteins in bile were affected differently with extreme decreases in IgA, moderate decreases in total protein and leucine aminopeptidase, and minimal change in transferrin. By 2 h after pressure release, only the alterations in biliary glucose and IgA persisted. The observed striking and persisting increases in biliary glucose are tentatively explained as an impaired reabsorption of glucose by the biliary tract.

Original languageEnglish (US)
Pages (from-to)89-97
Number of pages9
JournalJournal of Hepatology
Volume16
Issue number1-2
DOIs
StatePublished - 1992

Fingerprint

Hydrostatic Pressure
Transferrin
Bile
Immunoglobulin A
Phosphates
Glucose
Pressure
Leucyl Aminopeptidase
Taurocholic Acid
Biliary Tract
Bile Ducts
Bile Acids and Salts
Proteins

Keywords

  • Biliary permeability
  • Biliary reabsorption
  • Cholestasis
  • Paracellular pathway

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Biliary endogenous inorganic phosphate, D-glucose, IgA and transferrin are differentially altered by hydrostatic pressure. / Moslen, Mary Treinen; Kanz, Mary F.; Bhatia, Jatinder; Kaphalia, Lata; Goldblum, Randall M.

In: Journal of Hepatology, Vol. 16, No. 1-2, 1992, p. 89-97.

Research output: Contribution to journalArticle

Moslen, Mary Treinen ; Kanz, Mary F. ; Bhatia, Jatinder ; Kaphalia, Lata ; Goldblum, Randall M. / Biliary endogenous inorganic phosphate, D-glucose, IgA and transferrin are differentially altered by hydrostatic pressure. In: Journal of Hepatology. 1992 ; Vol. 16, No. 1-2. pp. 89-97.
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