Abstract
Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10120-10123 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 54 |
| Issue number | 72 |
| DOIs | |
| State | Published - Jan 1 2018 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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Wang, P., Lo Cascio, F., Gao, J., Kayed, R., & Huang, X. (2018). Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides. Chemical Communications, 54(72), 10120-10123. https://doi.org/10.1039/c8cc05072d