Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

Peng Wang, Filippa Lo Cascio, Jia Gao, Rakez Kayed, Xuefei Huang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.

Original languageEnglish (US)
Pages (from-to)10120-10123
Number of pages4
JournalChemical Communications
Volume54
Issue number72
DOIs
StatePublished - Jan 1 2018

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Oligosaccharides
Poisons
Oligomers
Heparin
Cytotoxicity

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides. / Wang, Peng; Lo Cascio, Filippa; Gao, Jia; Kayed, Rakez; Huang, Xuefei.

In: Chemical Communications, Vol. 54, No. 72, 01.01.2018, p. 10120-10123.

Research output: Contribution to journalArticle

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