Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

Peng Wang, Filippa Lo Cascio, Jia Gao, Rakez Kayed, Xuefei Huang

    Research output: Contribution to journalArticlepeer-review

    17 Scopus citations

    Abstract

    Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.

    Original languageEnglish (US)
    Pages (from-to)10120-10123
    Number of pages4
    JournalChemical Communications
    Volume54
    Issue number72
    DOIs
    StatePublished - 2018

    ASJC Scopus subject areas

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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