Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

Peng Wang; Filippa Lo Cascio; Jia Gao; Rakez Kayed; Xuefei Huang

doi:10.1039/c8cc05072d

Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

Peng Wang, Filippa Lo Cascio, Jia Gao, Rakez Kayed, Xuefei Huang

Neurology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM K_D. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.

Original language	English (US)
Pages (from-to)	10120-10123
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	72
DOIs	https://doi.org/10.1039/c8cc05072d
State	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.",

author = "Peng Wang and {Lo Cascio}, Filippa and Jia Gao and Rakez Kayed and Xuefei Huang",

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AU - Wang, Peng

AU - Lo Cascio, Filippa

AU - Gao, Jia

AU - Kayed, Rakez

AU - Huang, Xuefei

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2018

Y1 - 2018

N2 - Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.

AB - Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.

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Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

Abstract

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