Abstract
Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10120-10123 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 54 |
| Issue number | 72 |
| DOIs | |
| State | Published - Jan 1 2018 |
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ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
Cite this
Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides. / Wang, Peng; Lo Cascio, Filippa; Gao, Jia; Kayed, Rakez; Huang, Xuefei.
In: Chemical Communications, Vol. 54, No. 72, 01.01.2018, p. 10120-10123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides
AU - Wang, Peng
AU - Lo Cascio, Filippa
AU - Gao, Jia
AU - Kayed, Rakez
AU - Huang, Xuefei
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.
AB - Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.
UR - http://www.scopus.com/inward/record.url?scp=85053016072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053016072&partnerID=8YFLogxK
U2 - 10.1039/c8cc05072d
DO - 10.1039/c8cc05072d
M3 - Article
C2 - 30128457
AN - SCOPUS:85053016072
VL - 54
SP - 10120
EP - 10123
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 72
ER -