Bioactive lipids and circulating progenitor cells in patients with cardiovascular disease

Salim S. Hayek; Yuri Klyachkin; Ahmed Asfour; Nima Ghasemzadeh; Mosaab Awad; Iraj Hesaroieh; Hina Ahmed; Brandon Gray; Jinhee Kim; Edmund K. Waller; Arshed A. Quyyumi; Ahmed K. Abdel-Latif

doi:10.5966/sctm.2016-0059

Bioactive lipids and circulating progenitor cells in patients with cardiovascular disease

Salim S. Hayek, Yuri Klyachkin, Ahmed Asfour, Nima Ghasemzadeh, Mosaab Awad, Iraj Hesaroieh, Hina Ahmed, Brandon Gray, Jinhee Kim, Edmund K. Waller, Arshed A. Quyyumi, Ahmed K. Abdel-Latif

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry. CPCs were assessed using flow cytometry. S1P levels correlated with the numbers of CD341, CD341/CD1331, and CD341/CXCR41CPCs even after adjustment for potential confounding factors. However, no significant correlation was observed between C1P levels and CPC count. Plasma levels of S1P correlated with the number of CPCs in patients with coronary artery disease, suggesting an important mechanistic role for S1P in stem cell mobilization. The therapeutic effects of adjunctive S1P therapy to mobilize endogenous stem cells need to be investigated.

Original language	English (US)
Pages (from-to)	731-735
Number of pages	5
Journal	Stem Cells Translational Medicine
Volume	6
Issue number	3
DOIs	https://doi.org/10.5966/sctm.2016-0059
State	Published - Mar 2017
Externally published	Yes

Keywords

Ceramide-1 phosphate
Circulating progenitor cell
Coronary artery disease
Mobilization
Sphingosine-1 phosphate

ASJC Scopus subject areas

General Medicine

Access to Document

10.5966/sctm.2016-0059

Cite this

@article{563f4e53279841829b92409019c16968,

title = "Bioactive lipids and circulating progenitor cells in patients with cardiovascular disease",

abstract = "Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry. CPCs were assessed using flow cytometry. S1P levels correlated with the numbers of CD341, CD341/CD1331, and CD341/CXCR41CPCs even after adjustment for potential confounding factors. However, no significant correlation was observed between C1P levels and CPC count. Plasma levels of S1P correlated with the number of CPCs in patients with coronary artery disease, suggesting an important mechanistic role for S1P in stem cell mobilization. The therapeutic effects of adjunctive S1P therapy to mobilize endogenous stem cells need to be investigated.",

keywords = "Ceramide-1 phosphate, Circulating progenitor cell, Coronary artery disease, Mobilization, Sphingosine-1 phosphate",

author = "Hayek, {Salim S.} and Yuri Klyachkin and Ahmed Asfour and Nima Ghasemzadeh and Mosaab Awad and Iraj Hesaroieh and Hina Ahmed and Brandon Gray and Jinhee Kim and Waller, {Edmund K.} and Quyyumi, {Arshed A.} and Abdel-Latif, {Ahmed K.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors.",

year = "2017",

month = mar,

doi = "10.5966/sctm.2016-0059",

language = "English (US)",

volume = "6",

pages = "731--735",

journal = "Stem Cells Translational Medicine",

issn = "2157-6564",

publisher = "AlphaMed Press",

number = "3",

}

TY - JOUR

T1 - Bioactive lipids and circulating progenitor cells in patients with cardiovascular disease

AU - Hayek, Salim S.

AU - Klyachkin, Yuri

AU - Asfour, Ahmed

AU - Ghasemzadeh, Nima

AU - Awad, Mosaab

AU - Hesaroieh, Iraj

AU - Ahmed, Hina

AU - Gray, Brandon

AU - Kim, Jinhee

AU - Waller, Edmund K.

AU - Quyyumi, Arshed A.

AU - Abdel-Latif, Ahmed K.

PY - 2017/3

Y1 - 2017/3

N2 - Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry. CPCs were assessed using flow cytometry. S1P levels correlated with the numbers of CD341, CD341/CD1331, and CD341/CXCR41CPCs even after adjustment for potential confounding factors. However, no significant correlation was observed between C1P levels and CPC count. Plasma levels of S1P correlated with the number of CPCs in patients with coronary artery disease, suggesting an important mechanistic role for S1P in stem cell mobilization. The therapeutic effects of adjunctive S1P therapy to mobilize endogenous stem cells need to be investigated.

AB - Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry. CPCs were assessed using flow cytometry. S1P levels correlated with the numbers of CD341, CD341/CD1331, and CD341/CXCR41CPCs even after adjustment for potential confounding factors. However, no significant correlation was observed between C1P levels and CPC count. Plasma levels of S1P correlated with the number of CPCs in patients with coronary artery disease, suggesting an important mechanistic role for S1P in stem cell mobilization. The therapeutic effects of adjunctive S1P therapy to mobilize endogenous stem cells need to be investigated.

KW - Ceramide-1 phosphate

KW - Circulating progenitor cell

KW - Coronary artery disease

KW - Mobilization

KW - Sphingosine-1 phosphate

UR - http://www.scopus.com/inward/record.url?scp=85017539802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017539802&partnerID=8YFLogxK

U2 - 10.5966/sctm.2016-0059

DO - 10.5966/sctm.2016-0059

M3 - Article

C2 - 28297574

AN - SCOPUS:85017539802

SN - 2157-6564

VL - 6

SP - 731

EP - 735

JO - Stem Cells Translational Medicine

JF - Stem Cells Translational Medicine

IS - 3

ER -

Bioactive lipids and circulating progenitor cells in patients with cardiovascular disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this