Biobrane® improves wound healing in burned children without increased risk of infection

Sophia Lal, Robert E. Barrow, Steven Wolf, David L. Chinkes, David W. Hart, John P. Heggers, David Herndon

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

A synthetic bilaminar membrane used as a skin substitute (Biobrane®) has been shown to decrease pain and hospitalization in superficial second-degree burns. Despite these benefits, it has not been utilized universally, particularly in young children, due to a perceived increase in related infections. We propose that when this synthetic membrane is applied to superficial scald burns <25% of the total body surface area (TBSA), decreased healing times are expected without increased risk of infection. Between 1994-1999, 89 children treated within 48 h after receiving superficial partial thickness scald burns covering 5-25% TBSA with no indication of infection were seen at our hospital. Forty-one were assigned randomly to receive treatment with the skin substitute Biobrane and 48 to receive conservative treatment with topical antimicrobials and dressing changes. Comparisons of treatment were made between groups for length of hospitalization, wound healing times, and infectious complications. Children treated with Biobrane or topical antimicrobials were similar in age, race, sex, %TBSA burned, and location of burn. Those receiving Biobrane had shorter hospitalizations and healing times, which was significant for both infants and toddlers and older children. Treatment groups were not different in the use of systemic antibiotics or readmissions for infectious complications. Biobrane was removed in 5.9% of cases for non-adherence. The application of Biobrane within 48 h of superficial burns provides for shorter hospitalizations and faster healing times in children of all ages without increased risk of infection.

Original languageEnglish (US)
Pages (from-to)314-319
Number of pages6
JournalShock
Volume14
Issue number3
StatePublished - Sep 2000

Fingerprint

Wound Healing
Burns
Body Surface Area
Infection
Artificial Skin
Hospitalization
Hospitalization Insurance
Membranes
Bandages
Biobrane
Therapeutics
Anti-Bacterial Agents
Pain

Keywords

  • Biobrane
  • Burn infection
  • Partial thickness burns
  • Scald burns
  • Silver sulfadiazine
  • Synthetic skin substitute

ASJC Scopus subject areas

  • Physiology
  • Critical Care and Intensive Care Medicine

Cite this

Lal, S., Barrow, R. E., Wolf, S., Chinkes, D. L., Hart, D. W., Heggers, J. P., & Herndon, D. (2000). Biobrane® improves wound healing in burned children without increased risk of infection. Shock, 14(3), 314-319.

Biobrane® improves wound healing in burned children without increased risk of infection. / Lal, Sophia; Barrow, Robert E.; Wolf, Steven; Chinkes, David L.; Hart, David W.; Heggers, John P.; Herndon, David.

In: Shock, Vol. 14, No. 3, 09.2000, p. 314-319.

Research output: Contribution to journalArticle

Lal, S, Barrow, RE, Wolf, S, Chinkes, DL, Hart, DW, Heggers, JP & Herndon, D 2000, 'Biobrane® improves wound healing in burned children without increased risk of infection', Shock, vol. 14, no. 3, pp. 314-319.
Lal S, Barrow RE, Wolf S, Chinkes DL, Hart DW, Heggers JP et al. Biobrane® improves wound healing in burned children without increased risk of infection. Shock. 2000 Sep;14(3):314-319.
Lal, Sophia ; Barrow, Robert E. ; Wolf, Steven ; Chinkes, David L. ; Hart, David W. ; Heggers, John P. ; Herndon, David. / Biobrane® improves wound healing in burned children without increased risk of infection. In: Shock. 2000 ; Vol. 14, No. 3. pp. 314-319.
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