Biobrane versus 1% silver sulfadiazine in second-degree pediatric burns

Juan P. Barret, Peter Dziewulski, Peter I. Ramzy, Steven Wolf, Manubhai H. Desai, David Herndon

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Partial-thickness burns in children have been treated for many years by daily, painful tubbing, washing, and cleansing of the burn wound, followed by topical application of antimicrobial creams. Pain and impaired wound healing are the main problems. We hypothesized that the treatment of second-degree burns with Biobrane is superior to topical treatment. Twenty pediatric patients were prospectively randomized in two groups to compare the efficacy of Biobrane versus 1% silver sulfadiazine. The rest of the routine clinical protocols were followed in both groups. Demographic data, wound healing time, length of hospital stay, pain assessments and pain medication requirements, and infection were analyzed and compared. Main outcome measures included pain, pain medication requirements, wound healing time, length of hospital stay, and infection. The application of Biobrane to partial-thickness burns proved to be superior to the topical treatment. Patients included in the biosynthetic temporary cover group presented with less pain and required less pain medication. Length of hospital stay and wound healing time were also significantly shorter in the Biobrane group. None of the patients in either group presented with wound infection or needed skin autografting. In conclusion, the treatment of partial-thickness burns with Biobrane is superior to topical therapy with 1% silver sulfadiazine. Pain, pain medication requirements, wound healing time, and length of hospital stay are significantly reduced.

Original languageEnglish (US)
Pages (from-to)62-65
Number of pages4
JournalPlastic and Reconstructive Surgery
Volume105
Issue number1
StatePublished - Jan 2000

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Silver Sulfadiazine
Burns
Length of Stay
Pediatrics
Pain
Wound Healing
Therapeutics
Biobrane
Autologous Transplantation
Wound Infection
Pain Measurement
Clinical Protocols
Cross Infection
Demography
Outcome Assessment (Health Care)
Skin

ASJC Scopus subject areas

  • Surgery

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Biobrane versus 1% silver sulfadiazine in second-degree pediatric burns. / Barret, Juan P.; Dziewulski, Peter; Ramzy, Peter I.; Wolf, Steven; Desai, Manubhai H.; Herndon, David.

In: Plastic and Reconstructive Surgery, Vol. 105, No. 1, 01.2000, p. 62-65.

Research output: Contribution to journalArticle

Barret, Juan P. ; Dziewulski, Peter ; Ramzy, Peter I. ; Wolf, Steven ; Desai, Manubhai H. ; Herndon, David. / Biobrane versus 1% silver sulfadiazine in second-degree pediatric burns. In: Plastic and Reconstructive Surgery. 2000 ; Vol. 105, No. 1. pp. 62-65.
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