Biochemical markers of neonatal hypoxia

Megan S. Plank, Danilo S. Boskovic, Lawrence C. Sowers, Danilyn M. Angeles

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Neonatal hypoxia is a clinical condition with detrimental biochemical and clinical outcomes, including production of reactive oxygen and nitrogen species, ATP depletion, developmental abnormalities and growth retardation. Diagnostic approaches for hypoxia are largely based on nonspecific clinical criteria, such as Apgar score, umbilical cord pH and fetal heart-rate monitoring. Since our understanding of the biochemical processes of hypoxia has improved, several biochemical markers have been developed. This article highlights the use of hypoxanthine, xanthine, uric acid, xanthine oxidase, malondialdehyde, nitrotyrosine and lactate as markers of hypoxia in animal models, preterm neonates and full-term neonates.

Original languageEnglish (US)
Pages (from-to)485-501
Number of pages17
JournalPediatric Health
Volume2
Issue number4
DOIs
StatePublished - Aug 1 2008
Externally publishedYes

Keywords

  • Hypoxanthine
  • Malondialdehyde
  • Neoltal hypoxia
  • Nitrotyrosine
  • Uric acid
  • Xanthine
  • Xanthine oxidase

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

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  • Cite this

    Plank, M. S., Boskovic, D. S., Sowers, L. C., & Angeles, D. M. (2008). Biochemical markers of neonatal hypoxia. Pediatric Health, 2(4), 485-501. https://doi.org/10.2217/17455111.2.4.485