Biochemical markers of neonatal hypoxia

Megan S. Plank, Danilo S. Boskovic, Lawrence Sowers, Danilyn M. Angeles

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Neonatal hypoxia is a clinical condition with detrimental biochemical and clinical outcomes, including production of reactive oxygen and nitrogen species, ATP depletion, developmental abnormalities and growth retardation. Diagnostic approaches for hypoxia are largely based on nonspecific clinical criteria, such as Apgar score, umbilical cord pH and fetal heart-rate monitoring. Since our understanding of the biochemical processes of hypoxia has improved, several biochemical markers have been developed. This article highlights the use of hypoxanthine, xanthine, uric acid, xanthine oxidase, malondialdehyde, nitrotyrosine and lactate as markers of hypoxia in animal models, preterm neonates and full-term neonates.

Original languageEnglish (US)
Pages (from-to)485-501
Number of pages17
JournalPediatric Health
Volume2
Issue number4
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Biomarkers
Biochemical Phenomena
Reactive Nitrogen Species
Fetal Heart Rate
Hypoxanthine
Xanthine
Apgar Score
Xanthine Oxidase
Umbilical Cord
Uric Acid
Malondialdehyde
Lactic Acid
Reactive Oxygen Species
Animal Models
Adenosine Triphosphate
Hypoxia
Growth

Keywords

  • Hypoxanthine
  • Malondialdehyde
  • Neoltal hypoxia
  • Nitrotyrosine
  • Uric acid
  • Xanthine
  • Xanthine oxidase

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

Cite this

Plank, M. S., Boskovic, D. S., Sowers, L., & Angeles, D. M. (2008). Biochemical markers of neonatal hypoxia. Pediatric Health, 2(4), 485-501. https://doi.org/10.2217/17455111.2.4.485

Biochemical markers of neonatal hypoxia. / Plank, Megan S.; Boskovic, Danilo S.; Sowers, Lawrence; Angeles, Danilyn M.

In: Pediatric Health, Vol. 2, No. 4, 08.2008, p. 485-501.

Research output: Contribution to journalArticle

Plank, MS, Boskovic, DS, Sowers, L & Angeles, DM 2008, 'Biochemical markers of neonatal hypoxia', Pediatric Health, vol. 2, no. 4, pp. 485-501. https://doi.org/10.2217/17455111.2.4.485
Plank, Megan S. ; Boskovic, Danilo S. ; Sowers, Lawrence ; Angeles, Danilyn M. / Biochemical markers of neonatal hypoxia. In: Pediatric Health. 2008 ; Vol. 2, No. 4. pp. 485-501.
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