Biodegradable polymeric nanocarriers for pulmonary drug delivery

Erik Rytting, Juliane Nguyen, Xiaoying Wang, Thomas Kissel

Research output: Contribution to journalReview article

159 Scopus citations

Abstract

Background: Pulmonary drug delivery is attractive for both local and systemic drug delivery as a non-invasive route that provides a large surface area, thin epithelial barrier, high blood flow and the avoidance of first-pass metabolism. Objective: Nanoparticles can be designed to have several advantages for controlled and targeted drug delivery, including controlled deposition, sustained release, reduced dosing frequency, as well as an appropriate size for avoiding alveolar macrophage clearance or promoting transepithelial transport. Methods: This review focuses on the development and application of biodegradable polymers to nanocarrier-based strategies for the delivery of drugs, peptides, proteins, genes, siRNA and vaccines by the pulmonary route. Results/conclusion: The selection of natural or synthetic materials is important in designing particles or nanoparticle clusters with the desired characteristics, such as biocompatibility, size, charge, drug release and polymer degradation rate.

Original languageEnglish (US)
Pages (from-to)629-639
Number of pages11
JournalExpert Opinion on Drug Delivery
Volume5
Issue number6
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

Keywords

  • Biodegradable polymers
  • Gene and siRNA delivery
  • Nanoparticles
  • Peptides
  • Proteins
  • Pulmonary drug delivery

ASJC Scopus subject areas

  • Pharmaceutical Science

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