Biological action of leptin as an angiogenic factor

M. Rocío Sierra-Honigmann, Anjali K. Nath, Chiaki Murakami, Guillermo García-Cardeña, Andreas Papapetropoulos, William C. Sessa, Lisa A. Madge, Jeffrey S. Schechner, Michael B. Schwabb, Peter J. Polverini, Jaime R. Flores-Riveros

Research output: Contribution to journalArticle

1213 Scopus citations

Abstract

Leptin is a hormone that regulates food intake, and its receptor (OB- Rb) is expressed primarily in the hypothalamus. Here, it is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial cells. In vitro and in vivo assays revealed that leptin has angiogenic activity. In vivo, leptin induced neovascularization in corneas from normal rats but not in corneas from falfa Zucker rats, which lack functional leptin receptors. These observations indicate that the vascular endothelium is a target for leptin and suggest a physiological mechanism whereby leptin-induced angiogenesis may facilitate increased energy expenditures.

Original languageEnglish (US)
Pages (from-to)1683-1686
Number of pages4
JournalScience
Volume281
Issue number5383
DOIs
StatePublished - Sep 11 1998
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Sierra-Honigmann, M. R., Nath, A. K., Murakami, C., García-Cardeña, G., Papapetropoulos, A., Sessa, W. C., Madge, L. A., Schechner, J. S., Schwabb, M. B., Polverini, P. J., & Flores-Riveros, J. R. (1998). Biological action of leptin as an angiogenic factor. Science, 281(5383), 1683-1686. https://doi.org/10.1126/science.281.5383.1683