Biological properties of T6S cells, a clone of burn-associated type 2 T cells

Natsuki Nakajima, Tokuichiro Utsunomiya, Makiko Kobayashi, Richard B. Pollard, Fujio Suzuki

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A clone of type 2 T cells (T 6 S cell) was established from burn-associated CD 8+ CD 11 b+ TCRY/δ+ type 2 T cells, and their biological properties were examined. After stimulation by anti-CD 3 monoclonal antibody (mAb), T 6 S cells produced IL-4 and IL-10 into their culture fluids. However, IFN-γ and IL-2 were not demonstrated in the culture fluids of T 6 S cells stimulated with the mAb. The susceptibility of thermally injured mice to infection with herpes simplex virus type 1 (HSV-1) or Candida albicans (C. albicans) has been shown to be approximately 50 (C. albicans) to 100 (HSV-1) times greater than that of normal mice. As compared with the resistance of thermally injured mice to these pathogens, mice inoculated with 1×106 cells/mouse of T 6 S cells (designated as T 6 S-mice) showed the same susceptibility to the infections. When T 6 S-mice treated with a mixture of monoclonal antibodies (mAbs) directed against IL-4 and IL-10 were infected with a lethal dose of HSV-1 or C. albicans, their resistance to these pathogens was restored to levels found in normal mice. From the experiments using T 6 S-mice, it is suggest that type 2 T cells or their cytokine products (IL-4 and IL-10) may play an important role on the impaired resistance of thermally injured mice to certain opportunistic pathogens. T 6 S cell may be a useful tool to study opportunistic infections in hosts bearing type 2 T cells.

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalJapanese Journal of Clinical Immunology
Volume22
Issue number3
DOIs
StatePublished - Jan 1 1999

Keywords

  • Burn-associated type 2 T cell
  • Candida albicans
  • HSV
  • T 6 S cell
  • Type 2 T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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