Biological Rationale for the Repurposing of BCG Vaccine against SARS-CoV-2

Sanja Glisic, Vladimir R. Perovic, Milan Sencanski, Slobodan Paessler, Veljko Veljkovic

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The Bacillus Calmette-Guerin vaccine is still widely used in the developing world. The vaccination prevents infant death not only from tuberculosis but also from unrelated infectious agents, especially respiratory tract infections and neonatal sepsis. It is proposed that these off-target protective effects of the BCG vaccine are mediated by the general long-term boosting of innate immune mechanisms, also termed "trained innate immunity". Recent studies indicate that both COVID-19 incidence and total deaths are strongly associated with the presence or absence of national mandatory BCG vaccination programs and encourage the initiation of several clinical studies with the expectation that revaccination with BCG could reduce the incidence and severity of COVID-19. Here, presented results from the bioinformatics analysis of the Mycobacterium bovis (strain BCG/Pasteur 1173P2) proteome suggests four immunodominant antigens that could induce an immune response against SARS-CoV-2.

Original languageEnglish (US)
Pages (from-to)4649-4654
Number of pages6
JournalJournal of Proteome Research
Volume19
Issue number11
DOIs
StatePublished - Nov 6 2020

Keywords

  • BCG
  • COVID-19
  • SARS-CoV-2
  • clinical study
  • vaccine

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

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