Biology of Arboledas virus, a new phlebotomus fever serogroup virus (Bunyaviridae: Phlebovirus) isolated from sand flies in Colombia

R. B. Tesh, S. J. Boshell, D. G. Young, A. Morales, A. Corredor, G. B. Modi, C. Ferro de Carrasquilla, C. de Rodriquez, M. O. Gaitan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Six isolates of a new phlebotomus fever serogroup virus, designated Arboledas virus, were obtained from sand flies (Lutzomyia spp.) collected in northeastern Colombia. One of the isolates was made from a pool of male sand flies. By immunofluorescence, Arboledas virus is related to Caimito and Pacui viruses; by neutralization test, it is distinct. Arboledas virus neutralizing antibodies were found in the sera of opossums (Didelphis marsupialis) and humans living in the study area. D. marsupialis inoculated with the virus developed a viremia of four days' duration, and sand flies (Lutzomyia gomezi) feeding on a viremic opossum were readily infected. Transovarial transmission of Arboledas virus was also demonstrated in experimentally infected Lu. gomezi. Results of the above laboratory studies suggest that Arboledas virus is maintained in nature by two mechanisms: vertical (transovarial) transmission in the insect vector, and an alternating marsupial-sand fly cycle. The implications of this complex maintenance cycle for other phleboviruses are discussed.

Original languageEnglish (US)
Pages (from-to)1310-1316
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume35
Issue number6
StatePublished - 1986
Externally publishedYes

Fingerprint

Phlebotomus Fever
Phlebovirus
Bunyaviridae
Psychodidae
Colombia
Viruses
Opossums
Didelphis
Insect Vectors
Marsupialia
Neutralization Tests
Serogroup
Viremia
Neutralizing Antibodies
Fluorescent Antibody Technique
Maintenance

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Tesh, R. B., Boshell, S. J., Young, D. G., Morales, A., Corredor, A., Modi, G. B., ... Gaitan, M. O. (1986). Biology of Arboledas virus, a new phlebotomus fever serogroup virus (Bunyaviridae: Phlebovirus) isolated from sand flies in Colombia. American Journal of Tropical Medicine and Hygiene, 35(6), 1310-1316.

Biology of Arboledas virus, a new phlebotomus fever serogroup virus (Bunyaviridae : Phlebovirus) isolated from sand flies in Colombia. / Tesh, R. B.; Boshell, S. J.; Young, D. G.; Morales, A.; Corredor, A.; Modi, G. B.; Ferro de Carrasquilla, C.; de Rodriquez, C.; Gaitan, M. O.

In: American Journal of Tropical Medicine and Hygiene, Vol. 35, No. 6, 1986, p. 1310-1316.

Research output: Contribution to journalArticle

Tesh, RB, Boshell, SJ, Young, DG, Morales, A, Corredor, A, Modi, GB, Ferro de Carrasquilla, C, de Rodriquez, C & Gaitan, MO 1986, 'Biology of Arboledas virus, a new phlebotomus fever serogroup virus (Bunyaviridae: Phlebovirus) isolated from sand flies in Colombia', American Journal of Tropical Medicine and Hygiene, vol. 35, no. 6, pp. 1310-1316.
Tesh, R. B. ; Boshell, S. J. ; Young, D. G. ; Morales, A. ; Corredor, A. ; Modi, G. B. ; Ferro de Carrasquilla, C. ; de Rodriquez, C. ; Gaitan, M. O. / Biology of Arboledas virus, a new phlebotomus fever serogroup virus (Bunyaviridae : Phlebovirus) isolated from sand flies in Colombia. In: American Journal of Tropical Medicine and Hygiene. 1986 ; Vol. 35, No. 6. pp. 1310-1316.
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