Biomarkers of Plasmodium falciparum Infection during Pregnancy in Women Living in Northeastern Tanzania

Stéphanie Boström, Akanni Adededji Abdoul Ibitokou, Mayke Oesterholt, Christentze Schmiegelow, Jan Olov Persson, Daniel Minja, John Lusingu, Martha Lemnge, Nadine Fievet, Philippe Deloron, Adrian J F Luty, Marita Troye-Blomberg

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In pregnant women, Plasmodium falciparum infections are an important cause of maternal morbidity as well as fetal and neonatal mortality. Erythrocytes infected by these malaria-causing parasites accumulate through adhesive interactions in placental intervillous spaces, thus evading detection in peripheral blood smears. Sequestered infected erythrocytes induce inflammation, offering the possibility of detecting inflammatory mediators in peripheral blood that could act as biomarkers of placental infection. In a longitudinal, prospective study in Tanzania, we quantified a range of different cytokines, chemokines and angiogenic factors in peripheral plasma samples, taken on multiple sequential occasions during pregnancy up to and including delivery, from P. falciparum-infected women and matched uninfected controls. The results show that during healthy, uninfected pregnancies the levels of most of the panel of molecules we measured were largely unchanged except at delivery. In women with P. falciparum, however, both comparative and longitudinal assessments consistently showed that the levels of IL-10 and IP-10 increased significantly whilst that of RANTES decreased significantly, regardless of gestational age at the time the infection was detected. ROC curve analysis indicated that a combination of increased IL-10 and IP-10 levels and decreased RANTES levels might be predictive of P. falciparum infections. In conclusion, our data suggest that host biomarkers in peripheral blood may represent useful diagnostic markers of P. falciparum infection during pregnancy, but placental histology results would need to be included to verify these findings.

Original languageEnglish (US)
Article numbere48763
JournalPLoS One
Volume7
Issue number11
DOIs
StatePublished - Nov 14 2012
Externally publishedYes

Fingerprint

Tanzania
Plasmodium falciparum
Biomarkers
Malaria
Chemokine CCL5
biomarkers
Blood
pregnancy
Pregnancy
Interleukin-10
infection
interleukin-10
Histology
ROC Curve
Angiogenesis Inducing Agents
blood
Chemokines
erythrocytes
Erythrocytes
Adhesives

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Boström, S., Ibitokou, A. A. A., Oesterholt, M., Schmiegelow, C., Persson, J. O., Minja, D., ... Troye-Blomberg, M. (2012). Biomarkers of Plasmodium falciparum Infection during Pregnancy in Women Living in Northeastern Tanzania. PLoS One, 7(11), [e48763]. https://doi.org/10.1371/journal.pone.0048763

Biomarkers of Plasmodium falciparum Infection during Pregnancy in Women Living in Northeastern Tanzania. / Boström, Stéphanie; Ibitokou, Akanni Adededji Abdoul; Oesterholt, Mayke; Schmiegelow, Christentze; Persson, Jan Olov; Minja, Daniel; Lusingu, John; Lemnge, Martha; Fievet, Nadine; Deloron, Philippe; Luty, Adrian J F; Troye-Blomberg, Marita.

In: PLoS One, Vol. 7, No. 11, e48763, 14.11.2012.

Research output: Contribution to journalArticle

Boström, S, Ibitokou, AAA, Oesterholt, M, Schmiegelow, C, Persson, JO, Minja, D, Lusingu, J, Lemnge, M, Fievet, N, Deloron, P, Luty, AJF & Troye-Blomberg, M 2012, 'Biomarkers of Plasmodium falciparum Infection during Pregnancy in Women Living in Northeastern Tanzania', PLoS One, vol. 7, no. 11, e48763. https://doi.org/10.1371/journal.pone.0048763
Boström S, Ibitokou AAA, Oesterholt M, Schmiegelow C, Persson JO, Minja D et al. Biomarkers of Plasmodium falciparum Infection during Pregnancy in Women Living in Northeastern Tanzania. PLoS One. 2012 Nov 14;7(11). e48763. https://doi.org/10.1371/journal.pone.0048763
Boström, Stéphanie ; Ibitokou, Akanni Adededji Abdoul ; Oesterholt, Mayke ; Schmiegelow, Christentze ; Persson, Jan Olov ; Minja, Daniel ; Lusingu, John ; Lemnge, Martha ; Fievet, Nadine ; Deloron, Philippe ; Luty, Adrian J F ; Troye-Blomberg, Marita. / Biomarkers of Plasmodium falciparum Infection during Pregnancy in Women Living in Northeastern Tanzania. In: PLoS One. 2012 ; Vol. 7, No. 11.
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