Biomarkers of spontaneous preterm birth: A systematic review of studies using multiplex analysis

Jossimara Polettini, Teresa Cobo, Marian Kacerovsky, Angela E. Vinturache, Piotr Laudanski, Myrthe J C S Peelen, Hanns Helmer, Ronald F. Lamont, Jun Takeda, Jerome Lapointe, Maria Regina Torloni, Nanbert Zhong, Ramkumar Menon

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Despite decades of research on risk indicators of spontaneous preterm birth (PTB), reliable biomarkers are still not available to screen or diagnose high-risk pregnancies. Several biomarkers in maternal and fetal compartments have been mechanistically linked to PTB, but none of them are reliable predictors of pregnancy outcome. This systematic review was conducted to synthesize the knowledge on PTB biomarkers identified using multiplex analysis. Three electronic databases (PubMed, EMBASE and Web of Science) were searched for studies in any language reporting the use of multiplex assays for maternal biomarkers associated with PTB published from January 2005 to March 2014. Retrieved citations (3631) were screened, and relevant studies (33) were selected for full-text reading. Ten studies were included in the review. Forty-two PTB-related proteins were reported, and RANTES and IL-10 (three studies) followed by MIP-1β, GM-CSF, Eotaxin, and TNF-RI (two studies) were reported more than once in maternal serum. However, results could not be combined due to heterogeneity in type of sample, study population, assay, and analysis methods. By this systematic review, we conclude that multiplex assays are a potential technological advancement for identifying biomarkers of PTB, although no single or combination of biomarkers could be identified to predict PTB risk.

Original languageEnglish (US)
Pages (from-to)71-84
Number of pages14
JournalJournal of Perinatal Medicine
Volume45
Issue number1
DOIs
StatePublished - Jan 1 2017

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Keywords

  • Biological markers
  • cytokines
  • multiplex assay
  • prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Polettini, J., Cobo, T., Kacerovsky, M., Vinturache, A. E., Laudanski, P., Peelen, M. J. C. S., Helmer, H., Lamont, R. F., Takeda, J., Lapointe, J., Torloni, M. R., Zhong, N., & Menon, R. (2017). Biomarkers of spontaneous preterm birth: A systematic review of studies using multiplex analysis. Journal of Perinatal Medicine, 45(1), 71-84. https://doi.org/10.1515/jpm-2016-0097