Biomarkers of spontaneous preterm birth

A systematic review of studies using multiplex analysis

Jossimara Polettini, Teresa Cobo, Marian Kacerovsky, Angela E. Vinturache, Piotr Laudanski, Myrthe J C S Peelen, Hanns Helmer, Ronald F. Lamont, Jun Takeda, Jerome Lapointe, Maria Regina Torloni, Nanbert Zhong, Ramkumar Menon

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Despite decades of research on risk indicators of spontaneous preterm birth (PTB), reliable biomarkers are still not available to screen or diagnose high-risk pregnancies. Several biomarkers in maternal and fetal compartments have been mechanistically linked to PTB, but none of them are reliable predictors of pregnancy outcome. This systematic review was conducted to synthesize the knowledge on PTB biomarkers identified using multiplex analysis. Three electronic databases (PubMed, EMBASE and Web of Science) were searched for studies in any language reporting the use of multiplex assays for maternal biomarkers associated with PTB published from January 2005 to March 2014. Retrieved citations (3631) were screened, and relevant studies (33) were selected for full-text reading. Ten studies were included in the review. Forty-two PTB-related proteins were reported, and RANTES and IL-10 (three studies) followed by MIP-1β, GM-CSF, Eotaxin, and TNF-RI (two studies) were reported more than once in maternal serum. However, results could not be combined due to heterogeneity in type of sample, study population, assay, and analysis methods. By this systematic review, we conclude that multiplex assays are a potential technological advancement for identifying biomarkers of PTB, although no single or combination of biomarkers could be identified to predict PTB risk.

Original languageEnglish (US)
Pages (from-to)71-84
Number of pages14
JournalJournal of Perinatal Medicine
Volume45
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Premature Birth
Biomarkers
Mothers
High-Risk Pregnancy
Chemokine CCL5
Pregnancy Outcome
Granulocyte-Macrophage Colony-Stimulating Factor
PubMed
Interleukin-10
Reading
Language
Databases
Serum
Research
Population
Proteins

Keywords

  • Biological markers
  • cytokines
  • multiplex assay
  • prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Polettini, J., Cobo, T., Kacerovsky, M., Vinturache, A. E., Laudanski, P., Peelen, M. J. C. S., ... Menon, R. (2017). Biomarkers of spontaneous preterm birth: A systematic review of studies using multiplex analysis. Journal of Perinatal Medicine, 45(1), 71-84. https://doi.org/10.1515/jpm-2016-0097

Biomarkers of spontaneous preterm birth : A systematic review of studies using multiplex analysis. / Polettini, Jossimara; Cobo, Teresa; Kacerovsky, Marian; Vinturache, Angela E.; Laudanski, Piotr; Peelen, Myrthe J C S; Helmer, Hanns; Lamont, Ronald F.; Takeda, Jun; Lapointe, Jerome; Torloni, Maria Regina; Zhong, Nanbert; Menon, Ramkumar.

In: Journal of Perinatal Medicine, Vol. 45, No. 1, 01.01.2017, p. 71-84.

Research output: Contribution to journalReview article

Polettini, J, Cobo, T, Kacerovsky, M, Vinturache, AE, Laudanski, P, Peelen, MJCS, Helmer, H, Lamont, RF, Takeda, J, Lapointe, J, Torloni, MR, Zhong, N & Menon, R 2017, 'Biomarkers of spontaneous preterm birth: A systematic review of studies using multiplex analysis', Journal of Perinatal Medicine, vol. 45, no. 1, pp. 71-84. https://doi.org/10.1515/jpm-2016-0097
Polettini J, Cobo T, Kacerovsky M, Vinturache AE, Laudanski P, Peelen MJCS et al. Biomarkers of spontaneous preterm birth: A systematic review of studies using multiplex analysis. Journal of Perinatal Medicine. 2017 Jan 1;45(1):71-84. https://doi.org/10.1515/jpm-2016-0097
Polettini, Jossimara ; Cobo, Teresa ; Kacerovsky, Marian ; Vinturache, Angela E. ; Laudanski, Piotr ; Peelen, Myrthe J C S ; Helmer, Hanns ; Lamont, Ronald F. ; Takeda, Jun ; Lapointe, Jerome ; Torloni, Maria Regina ; Zhong, Nanbert ; Menon, Ramkumar. / Biomarkers of spontaneous preterm birth : A systematic review of studies using multiplex analysis. In: Journal of Perinatal Medicine. 2017 ; Vol. 45, No. 1. pp. 71-84.
@article{91d90078eced4e8a81b019c6172bad8e,
title = "Biomarkers of spontaneous preterm birth: A systematic review of studies using multiplex analysis",
abstract = "Despite decades of research on risk indicators of spontaneous preterm birth (PTB), reliable biomarkers are still not available to screen or diagnose high-risk pregnancies. Several biomarkers in maternal and fetal compartments have been mechanistically linked to PTB, but none of them are reliable predictors of pregnancy outcome. This systematic review was conducted to synthesize the knowledge on PTB biomarkers identified using multiplex analysis. Three electronic databases (PubMed, EMBASE and Web of Science) were searched for studies in any language reporting the use of multiplex assays for maternal biomarkers associated with PTB published from January 2005 to March 2014. Retrieved citations (3631) were screened, and relevant studies (33) were selected for full-text reading. Ten studies were included in the review. Forty-two PTB-related proteins were reported, and RANTES and IL-10 (three studies) followed by MIP-1β, GM-CSF, Eotaxin, and TNF-RI (two studies) were reported more than once in maternal serum. However, results could not be combined due to heterogeneity in type of sample, study population, assay, and analysis methods. By this systematic review, we conclude that multiplex assays are a potential technological advancement for identifying biomarkers of PTB, although no single or combination of biomarkers could be identified to predict PTB risk.",
keywords = "Biological markers, cytokines, multiplex assay, prematurity",
author = "Jossimara Polettini and Teresa Cobo and Marian Kacerovsky and Vinturache, {Angela E.} and Piotr Laudanski and Peelen, {Myrthe J C S} and Hanns Helmer and Lamont, {Ronald F.} and Jun Takeda and Jerome Lapointe and Torloni, {Maria Regina} and Nanbert Zhong and Ramkumar Menon",
year = "2017",
month = "1",
day = "1",
doi = "10.1515/jpm-2016-0097",
language = "English (US)",
volume = "45",
pages = "71--84",
journal = "Journal of Perinatal Medicine",
issn = "0300-5577",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "1",

}

TY - JOUR

T1 - Biomarkers of spontaneous preterm birth

T2 - A systematic review of studies using multiplex analysis

AU - Polettini, Jossimara

AU - Cobo, Teresa

AU - Kacerovsky, Marian

AU - Vinturache, Angela E.

AU - Laudanski, Piotr

AU - Peelen, Myrthe J C S

AU - Helmer, Hanns

AU - Lamont, Ronald F.

AU - Takeda, Jun

AU - Lapointe, Jerome

AU - Torloni, Maria Regina

AU - Zhong, Nanbert

AU - Menon, Ramkumar

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Despite decades of research on risk indicators of spontaneous preterm birth (PTB), reliable biomarkers are still not available to screen or diagnose high-risk pregnancies. Several biomarkers in maternal and fetal compartments have been mechanistically linked to PTB, but none of them are reliable predictors of pregnancy outcome. This systematic review was conducted to synthesize the knowledge on PTB biomarkers identified using multiplex analysis. Three electronic databases (PubMed, EMBASE and Web of Science) were searched for studies in any language reporting the use of multiplex assays for maternal biomarkers associated with PTB published from January 2005 to March 2014. Retrieved citations (3631) were screened, and relevant studies (33) were selected for full-text reading. Ten studies were included in the review. Forty-two PTB-related proteins were reported, and RANTES and IL-10 (three studies) followed by MIP-1β, GM-CSF, Eotaxin, and TNF-RI (two studies) were reported more than once in maternal serum. However, results could not be combined due to heterogeneity in type of sample, study population, assay, and analysis methods. By this systematic review, we conclude that multiplex assays are a potential technological advancement for identifying biomarkers of PTB, although no single or combination of biomarkers could be identified to predict PTB risk.

AB - Despite decades of research on risk indicators of spontaneous preterm birth (PTB), reliable biomarkers are still not available to screen or diagnose high-risk pregnancies. Several biomarkers in maternal and fetal compartments have been mechanistically linked to PTB, but none of them are reliable predictors of pregnancy outcome. This systematic review was conducted to synthesize the knowledge on PTB biomarkers identified using multiplex analysis. Three electronic databases (PubMed, EMBASE and Web of Science) were searched for studies in any language reporting the use of multiplex assays for maternal biomarkers associated with PTB published from January 2005 to March 2014. Retrieved citations (3631) were screened, and relevant studies (33) were selected for full-text reading. Ten studies were included in the review. Forty-two PTB-related proteins were reported, and RANTES and IL-10 (three studies) followed by MIP-1β, GM-CSF, Eotaxin, and TNF-RI (two studies) were reported more than once in maternal serum. However, results could not be combined due to heterogeneity in type of sample, study population, assay, and analysis methods. By this systematic review, we conclude that multiplex assays are a potential technological advancement for identifying biomarkers of PTB, although no single or combination of biomarkers could be identified to predict PTB risk.

KW - Biological markers

KW - cytokines

KW - multiplex assay

KW - prematurity

UR - http://www.scopus.com/inward/record.url?scp=85009756473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009756473&partnerID=8YFLogxK

U2 - 10.1515/jpm-2016-0097

DO - 10.1515/jpm-2016-0097

M3 - Review article

VL - 45

SP - 71

EP - 84

JO - Journal of Perinatal Medicine

JF - Journal of Perinatal Medicine

SN - 0300-5577

IS - 1

ER -