TY - JOUR
T1 - Biomarkers of spontaneous preterm birth
T2 - A systematic review of studies using multiplex analysis
AU - Polettini, Jossimara
AU - Cobo, Teresa
AU - Kacerovsky, Marian
AU - Vinturache, Angela E.
AU - Laudanski, Piotr
AU - Peelen, Myrthe J.C.S.
AU - Helmer, Hanns
AU - Lamont, Ronald F.
AU - Takeda, Jun
AU - Lapointe, Jerome
AU - Torloni, Maria Regina
AU - Zhong, Nanbert
AU - Menon, Ramkumar
N1 - Publisher Copyright:
© 2017 Walter de Gruyter GmbH, Berlin/Boston.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Despite decades of research on risk indicators of spontaneous preterm birth (PTB), reliable biomarkers are still not available to screen or diagnose high-risk pregnancies. Several biomarkers in maternal and fetal compartments have been mechanistically linked to PTB, but none of them are reliable predictors of pregnancy outcome. This systematic review was conducted to synthesize the knowledge on PTB biomarkers identified using multiplex analysis. Three electronic databases (PubMed, EMBASE and Web of Science) were searched for studies in any language reporting the use of multiplex assays for maternal biomarkers associated with PTB published from January 2005 to March 2014. Retrieved citations (3631) were screened, and relevant studies (33) were selected for full-text reading. Ten studies were included in the review. Forty-two PTB-related proteins were reported, and RANTES and IL-10 (three studies) followed by MIP-1β, GM-CSF, Eotaxin, and TNF-RI (two studies) were reported more than once in maternal serum. However, results could not be combined due to heterogeneity in type of sample, study population, assay, and analysis methods. By this systematic review, we conclude that multiplex assays are a potential technological advancement for identifying biomarkers of PTB, although no single or combination of biomarkers could be identified to predict PTB risk.
AB - Despite decades of research on risk indicators of spontaneous preterm birth (PTB), reliable biomarkers are still not available to screen or diagnose high-risk pregnancies. Several biomarkers in maternal and fetal compartments have been mechanistically linked to PTB, but none of them are reliable predictors of pregnancy outcome. This systematic review was conducted to synthesize the knowledge on PTB biomarkers identified using multiplex analysis. Three electronic databases (PubMed, EMBASE and Web of Science) were searched for studies in any language reporting the use of multiplex assays for maternal biomarkers associated with PTB published from January 2005 to March 2014. Retrieved citations (3631) were screened, and relevant studies (33) were selected for full-text reading. Ten studies were included in the review. Forty-two PTB-related proteins were reported, and RANTES and IL-10 (three studies) followed by MIP-1β, GM-CSF, Eotaxin, and TNF-RI (two studies) were reported more than once in maternal serum. However, results could not be combined due to heterogeneity in type of sample, study population, assay, and analysis methods. By this systematic review, we conclude that multiplex assays are a potential technological advancement for identifying biomarkers of PTB, although no single or combination of biomarkers could be identified to predict PTB risk.
KW - Biological markers
KW - cytokines
KW - multiplex assay
KW - prematurity
UR - http://www.scopus.com/inward/record.url?scp=85009756473&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009756473&partnerID=8YFLogxK
U2 - 10.1515/jpm-2016-0097
DO - 10.1515/jpm-2016-0097
M3 - Review article
C2 - 27514075
AN - SCOPUS:85009756473
SN - 0300-5577
VL - 45
SP - 71
EP - 84
JO - Journal of perinatal medicine
JF - Journal of perinatal medicine
IS - 1
ER -