Biomarkers of spontaneous preterm birth

An overview of the literature in the last four decades

Ramkumar Menon, Maria Regina Torloni, Chiara Voltolini, Michela Torricelli, Mario Merialdi, Ana Pilar Betrán, Mariana Widmer, Tomas Allen, Iulia Davydova, Zulfiya Khodjaeva, Poul Thorsen, Marian Kacerovsky, Vojtìch Tambor, Tytti Massinen, Judith Nace, Chander Arora

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background: Understanding spontaneous preterm birth ([PTB] < 37 weeks) is difficult due to heterogeneities associated with multitudes of risk factors and pathophysiological pathways. Several biomarkers are routinely used clinically for predicting preterm labor; however, these factors are either nonspecific or detected too late. Objective: Systematic review of literature on PTB biomarkers in the last 40 years to map out the existing knowledge and gaps in understanding PTB biomarkers. Search strategies: Five electronic databases were searched for human studies on PTB biomarkers published in any language between 1965 and 2008. Selection criteria: The phenotype of interest for final data extraction was exclusively spontaneous PTB with no rupture of membranes. Data extraction included (a) general characteristics of the study (clinical setting, period, and study design), (b) study/participant characteristics (inclusion and exclusion criteria, race/ethnicity, number of participants, gestational age at sampling, (c) characteristics of the biomarker (type, rationale for its selection, type of biological sample, and assay used, and (d) concentration of biomarkers in cases and controls. Data collection and analysis: The search yielded 7255 citations and data were extracted from 217 articles which met our inclusion and exclusion criteria. Main results: A total of 116 different biomarkers were reported and these were assayed 578 times in the 217 included studies. Over two thirds of the 217 studies were performed on North American or European populations. No reliable biomarkers emerged as a risk predictor of PTB. Conclusions: Identifying similar studies on biomarkers for the prediction of PTB was a very challenging task due heterogeneities in study design, sampling issues (types, timing and processing), assay methods, and analyses. Major areas of concern identified in this review include poor phenotype definition, nonideal study designs and poor rationale for biomarker selection and assays and population stratification issues.

Original languageEnglish (US)
Pages (from-to)1046-1070
Number of pages25
JournalReproductive Sciences
Volume18
Issue number11
DOIs
StatePublished - Nov 2011

Fingerprint

Premature Birth
Biomarkers
Phenotype
Sampling Studies
Premature Obstetric Labor
Biological Assay
Patient Selection
Population
Gestational Age
Rupture
Language
Databases
Membranes

Keywords

  • cytokines
  • intervention
  • pathways
  • prematurity
  • prevention
  • risk factors

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Menon, R., Torloni, M. R., Voltolini, C., Torricelli, M., Merialdi, M., Betrán, A. P., ... Arora, C. (2011). Biomarkers of spontaneous preterm birth: An overview of the literature in the last four decades. Reproductive Sciences, 18(11), 1046-1070. https://doi.org/10.1177/1933719111415548

Biomarkers of spontaneous preterm birth : An overview of the literature in the last four decades. / Menon, Ramkumar; Torloni, Maria Regina; Voltolini, Chiara; Torricelli, Michela; Merialdi, Mario; Betrán, Ana Pilar; Widmer, Mariana; Allen, Tomas; Davydova, Iulia; Khodjaeva, Zulfiya; Thorsen, Poul; Kacerovsky, Marian; Tambor, Vojtìch; Massinen, Tytti; Nace, Judith; Arora, Chander.

In: Reproductive Sciences, Vol. 18, No. 11, 11.2011, p. 1046-1070.

Research output: Contribution to journalArticle

Menon, R, Torloni, MR, Voltolini, C, Torricelli, M, Merialdi, M, Betrán, AP, Widmer, M, Allen, T, Davydova, I, Khodjaeva, Z, Thorsen, P, Kacerovsky, M, Tambor, V, Massinen, T, Nace, J & Arora, C 2011, 'Biomarkers of spontaneous preterm birth: An overview of the literature in the last four decades', Reproductive Sciences, vol. 18, no. 11, pp. 1046-1070. https://doi.org/10.1177/1933719111415548
Menon, Ramkumar ; Torloni, Maria Regina ; Voltolini, Chiara ; Torricelli, Michela ; Merialdi, Mario ; Betrán, Ana Pilar ; Widmer, Mariana ; Allen, Tomas ; Davydova, Iulia ; Khodjaeva, Zulfiya ; Thorsen, Poul ; Kacerovsky, Marian ; Tambor, Vojtìch ; Massinen, Tytti ; Nace, Judith ; Arora, Chander. / Biomarkers of spontaneous preterm birth : An overview of the literature in the last four decades. In: Reproductive Sciences. 2011 ; Vol. 18, No. 11. pp. 1046-1070.
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