Biomolecular advances in gastrointestinal hormones

R. J. Bold, J. Ishizuka, Courtney Townsend, J. C. Thompson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Gastrointestinal hormones are chemical messengers that regulate a broad range of physiologic functions. Although primarily expressed within tissues of the gut, these peptide hormones are widely distributed throughout the body and act on multiple target tissues. Furthermore, these regulatory peptides can exist in multiple molecular forms that may bind to multiple cell-surface receptors coupled to one of several possible signal transduction systems leading to diverse biologic responses. With such an expansive field to study, it is not surprising that gut endocrinologists have embraced the new techniques that are emerging from the revolution of molecular biology. Beginning with the first construction of a recombinant DNA molecule by Paul Berg in 1971, molecular biology has developed many new techniques that have been rapidly adopted by gut endocrinologists to enable a more detailed understanding of gastrointestinal function. The merging of these two fields has led to a new area of research, molecular gut endocrinology, or the study of gut physiology and endocrinology at the level of individual molecules (ranging from polypeptide-surface receptors to small-molecule second messengers to DNA sequences). Gut cells are constantly bombarded by numerous hormones, and the tightly regulated physiologic status of each cell is becoming more clearly understood.

Original languageEnglish (US)
Pages (from-to)1268-1273
Number of pages6
JournalArchives of Surgery
Volume128
Issue number11
StatePublished - 1993

Fingerprint

Gastrointestinal Hormones
Endocrinology
Molecular Biology
Peptides
Recombinant DNA
Peptide Hormones
Cell Surface Receptors
Second Messenger Systems
Signal Transduction
Hormones
Research
Endocrinologists

ASJC Scopus subject areas

  • Surgery

Cite this

Bold, R. J., Ishizuka, J., Townsend, C., & Thompson, J. C. (1993). Biomolecular advances in gastrointestinal hormones. Archives of Surgery, 128(11), 1268-1273.

Biomolecular advances in gastrointestinal hormones. / Bold, R. J.; Ishizuka, J.; Townsend, Courtney; Thompson, J. C.

In: Archives of Surgery, Vol. 128, No. 11, 1993, p. 1268-1273.

Research output: Contribution to journalArticle

Bold, RJ, Ishizuka, J, Townsend, C & Thompson, JC 1993, 'Biomolecular advances in gastrointestinal hormones', Archives of Surgery, vol. 128, no. 11, pp. 1268-1273.
Bold RJ, Ishizuka J, Townsend C, Thompson JC. Biomolecular advances in gastrointestinal hormones. Archives of Surgery. 1993;128(11):1268-1273.
Bold, R. J. ; Ishizuka, J. ; Townsend, Courtney ; Thompson, J. C. / Biomolecular advances in gastrointestinal hormones. In: Archives of Surgery. 1993 ; Vol. 128, No. 11. pp. 1268-1273.
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