Biophysical mechanism of the scavenger site near T cell-presented epitopes

S. Lu, Victor Reyes, C. M. Bositis, T. G. Goldschmidt, V. Lam, R. R. Torgerson, T. Ciardelli, L. Hardy, R. A. Lew, R. E. Humphreys

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We seek to identify consensus sequences in digested fragments of antigenic proteins regulating selection and major histocompatibility complex (MHC)-restricted presentation to T cells of epitopes within those fragments. One such pattern, of recurrent, hydrophobic sidechains forming a longitudinal hydrophobic strip when a sequence is coiled as an α-helix, is found in or near most T cell-presented epitopes. Such recurrent hydrophobicity may lead to protease-protected coiling of the fragment against endosomal membranes and transfer to MHC molecules. This concept leads to better identification of T cell-presented sequences and possibly to engineering of T cell-presented vaccines to affect their potency and MHC restriction.

Original languageEnglish (US)
Pages (from-to)3-7
Number of pages5
JournalVaccine
Volume10
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

T-Lymphocyte Epitopes
Major Histocompatibility Complex
epitopes
major histocompatibility complex
T-lymphocytes
T-Lymphocytes
Consensus Sequence
Hydrophobic and Hydrophilic Interactions
consensus sequence
Peptide Hydrolases
Vaccines
hydrophobicity
engineering
proteinases
Membranes
vaccines
Proteins
proteins

Keywords

  • Antigen processing
  • MHC molecules
  • peptide vaccines
  • T cell-presented epitope
  • α-helix

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Lu, S., Reyes, V., Bositis, C. M., Goldschmidt, T. G., Lam, V., Torgerson, R. R., ... Humphreys, R. E. (1992). Biophysical mechanism of the scavenger site near T cell-presented epitopes. Vaccine, 10(1), 3-7. https://doi.org/10.1016/0264-410X(92)90410-L

Biophysical mechanism of the scavenger site near T cell-presented epitopes. / Lu, S.; Reyes, Victor; Bositis, C. M.; Goldschmidt, T. G.; Lam, V.; Torgerson, R. R.; Ciardelli, T.; Hardy, L.; Lew, R. A.; Humphreys, R. E.

In: Vaccine, Vol. 10, No. 1, 1992, p. 3-7.

Research output: Contribution to journalArticle

Lu, S, Reyes, V, Bositis, CM, Goldschmidt, TG, Lam, V, Torgerson, RR, Ciardelli, T, Hardy, L, Lew, RA & Humphreys, RE 1992, 'Biophysical mechanism of the scavenger site near T cell-presented epitopes', Vaccine, vol. 10, no. 1, pp. 3-7. https://doi.org/10.1016/0264-410X(92)90410-L
Lu, S. ; Reyes, Victor ; Bositis, C. M. ; Goldschmidt, T. G. ; Lam, V. ; Torgerson, R. R. ; Ciardelli, T. ; Hardy, L. ; Lew, R. A. ; Humphreys, R. E. / Biophysical mechanism of the scavenger site near T cell-presented epitopes. In: Vaccine. 1992 ; Vol. 10, No. 1. pp. 3-7.
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AU - Goldschmidt, T. G.

AU - Lam, V.

AU - Torgerson, R. R.

AU - Ciardelli, T.

AU - Hardy, L.

AU - Lew, R. A.

AU - Humphreys, R. E.

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