Biophysics of substrate interaction: Influence on neural motility, differentiation, and repair

Simon W. Moore, Michael Sheetz

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

The identity and behavior of a cell is shaped by the molecular and mechanical composition of its surroundings. Molecular cues have firmly established roles in guiding both neuronal fate decisions and the migration of cells and axons. However, there is growing evidence that topographical and rigidity cues in the extracellular environment act synergistically with these molecular cues. Like chemical cues, physical factors do not elicit a fixed response, but rather one that depends on the sensory makeup of the cell. Moreover, from developmental studies and the plasticity of neural tissue, it is evident that there is dynamic feedback between physical and chemical factors to produce the final morphology. Here, we focus on our current understanding of how these physical cues shape cellular differentiation and migration, and discuss their relevance to repairing the injured nervous system.

Original languageEnglish (US)
Pages (from-to)1090-1101
Number of pages12
JournalDevelopmental Neurobiology
Volume71
Issue number11
DOIs
StatePublished - Nov 1 2011
Externally publishedYes

Keywords

  • Contact guidance
  • Durotaxis
  • Mechanotransduction
  • Rigidity
  • Topography

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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