Biventricular pacing reduces the induction of monomorphic ventricular tachycardia

A potential mechanism for arrhythmia suppression

Robert C. Kowal, Stephen L. Wasmund, Michael L. Smith, Niraj Sharma, George Carayannopoulos, Brian Le, John Cogan, Ali M. Kizilbash, Jose A. Joglar, Mohamed H. Hamdan

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objectives. The aim of the present study was to evaluate in a prospective randomized fashion the electrophysiologic effects of acute biventricular (BV) pacing. We hypothesized that (1) the local coupling interval in the left ventricle in response to right-sided ventricular premature beats is prolonged when BV pacing is applied during the drive train compared with right ventricular (RV) pacing, and (2) BV programmed electrical stimulation (PES) decreases the induction of ventricular arrhythmias compared with standard RV-PES, regardless of the presence of intraventricular conduction delay. Background. Previous studies have su ggested that BV pacing might decrease the frequency of ventricular arrhythmias; however, the mechanism of arrhythmia suppression remains unclear. Methods. Eighteen patients with coronary artery disease were randomized to RV-PES or BV-PES with a repeat study using the other pacing mode. The RV effective refractory periods were measured during RV-PES and BV-PES. In addition, the local LV S1-S2 coupling interval was measured at 600/450 ms and 400/350 ms during RV-PES and BV-PES. Results. BV-PES had no effect on RV effective refractory periods. On the other hand, the local LV S1-S2 coupling intervals increased significantly during BV-PES compared with RV-PES (P < .0001). Ventricular tachycardia was induced in six patients using RV-PES but in only one patient with BV-PES (RR = 83%, P = .01). No difference was observed in the induction of ventricular fibrillation. Conclusions. BV-PES significantly reduced the induction of ventricular tachycardia compared to RV-PES, with no significant effect on ventricular fibrillation induction. Our findings may help explain the reduced incidence of ventricular arrhythmias noted with chronic BV pacing.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalHeart Rhythm
Volume1
Issue number3
DOIs
StatePublished - Sep 2004
Externally publishedYes

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Cardiac Resynchronization Therapy
Ventricular Tachycardia
Electric Stimulation
Cardiac Arrhythmias
Ventricular Fibrillation
Ventricular Premature Complexes
Patient Rights

Keywords

  • Biventricular pacing
  • Electrophysiology
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Biventricular pacing reduces the induction of monomorphic ventricular tachycardia : A potential mechanism for arrhythmia suppression. / Kowal, Robert C.; Wasmund, Stephen L.; Smith, Michael L.; Sharma, Niraj; Carayannopoulos, George; Le, Brian; Cogan, John; Kizilbash, Ali M.; Joglar, Jose A.; Hamdan, Mohamed H.

In: Heart Rhythm, Vol. 1, No. 3, 09.2004, p. 295-300.

Research output: Contribution to journalArticle

Kowal, RC, Wasmund, SL, Smith, ML, Sharma, N, Carayannopoulos, G, Le, B, Cogan, J, Kizilbash, AM, Joglar, JA & Hamdan, MH 2004, 'Biventricular pacing reduces the induction of monomorphic ventricular tachycardia: A potential mechanism for arrhythmia suppression', Heart Rhythm, vol. 1, no. 3, pp. 295-300. https://doi.org/10.1016/j.hrthm.2004.05.008
Kowal, Robert C. ; Wasmund, Stephen L. ; Smith, Michael L. ; Sharma, Niraj ; Carayannopoulos, George ; Le, Brian ; Cogan, John ; Kizilbash, Ali M. ; Joglar, Jose A. ; Hamdan, Mohamed H. / Biventricular pacing reduces the induction of monomorphic ventricular tachycardia : A potential mechanism for arrhythmia suppression. In: Heart Rhythm. 2004 ; Vol. 1, No. 3. pp. 295-300.
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abstract = "Objectives. The aim of the present study was to evaluate in a prospective randomized fashion the electrophysiologic effects of acute biventricular (BV) pacing. We hypothesized that (1) the local coupling interval in the left ventricle in response to right-sided ventricular premature beats is prolonged when BV pacing is applied during the drive train compared with right ventricular (RV) pacing, and (2) BV programmed electrical stimulation (PES) decreases the induction of ventricular arrhythmias compared with standard RV-PES, regardless of the presence of intraventricular conduction delay. Background. Previous studies have su ggested that BV pacing might decrease the frequency of ventricular arrhythmias; however, the mechanism of arrhythmia suppression remains unclear. Methods. Eighteen patients with coronary artery disease were randomized to RV-PES or BV-PES with a repeat study using the other pacing mode. The RV effective refractory periods were measured during RV-PES and BV-PES. In addition, the local LV S1-S2 coupling interval was measured at 600/450 ms and 400/350 ms during RV-PES and BV-PES. Results. BV-PES had no effect on RV effective refractory periods. On the other hand, the local LV S1-S2 coupling intervals increased significantly during BV-PES compared with RV-PES (P < .0001). Ventricular tachycardia was induced in six patients using RV-PES but in only one patient with BV-PES (RR = 83{\%}, P = .01). No difference was observed in the induction of ventricular fibrillation. Conclusions. BV-PES significantly reduced the induction of ventricular tachycardia compared to RV-PES, with no significant effect on ventricular fibrillation induction. Our findings may help explain the reduced incidence of ventricular arrhythmias noted with chronic BV pacing.",
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T2 - A potential mechanism for arrhythmia suppression

AU - Kowal, Robert C.

AU - Wasmund, Stephen L.

AU - Smith, Michael L.

AU - Sharma, Niraj

AU - Carayannopoulos, George

AU - Le, Brian

AU - Cogan, John

AU - Kizilbash, Ali M.

AU - Joglar, Jose A.

AU - Hamdan, Mohamed H.

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N2 - Objectives. The aim of the present study was to evaluate in a prospective randomized fashion the electrophysiologic effects of acute biventricular (BV) pacing. We hypothesized that (1) the local coupling interval in the left ventricle in response to right-sided ventricular premature beats is prolonged when BV pacing is applied during the drive train compared with right ventricular (RV) pacing, and (2) BV programmed electrical stimulation (PES) decreases the induction of ventricular arrhythmias compared with standard RV-PES, regardless of the presence of intraventricular conduction delay. Background. Previous studies have su ggested that BV pacing might decrease the frequency of ventricular arrhythmias; however, the mechanism of arrhythmia suppression remains unclear. Methods. Eighteen patients with coronary artery disease were randomized to RV-PES or BV-PES with a repeat study using the other pacing mode. The RV effective refractory periods were measured during RV-PES and BV-PES. In addition, the local LV S1-S2 coupling interval was measured at 600/450 ms and 400/350 ms during RV-PES and BV-PES. Results. BV-PES had no effect on RV effective refractory periods. On the other hand, the local LV S1-S2 coupling intervals increased significantly during BV-PES compared with RV-PES (P < .0001). Ventricular tachycardia was induced in six patients using RV-PES but in only one patient with BV-PES (RR = 83%, P = .01). No difference was observed in the induction of ventricular fibrillation. Conclusions. BV-PES significantly reduced the induction of ventricular tachycardia compared to RV-PES, with no significant effect on ventricular fibrillation induction. Our findings may help explain the reduced incidence of ventricular arrhythmias noted with chronic BV pacing.

AB - Objectives. The aim of the present study was to evaluate in a prospective randomized fashion the electrophysiologic effects of acute biventricular (BV) pacing. We hypothesized that (1) the local coupling interval in the left ventricle in response to right-sided ventricular premature beats is prolonged when BV pacing is applied during the drive train compared with right ventricular (RV) pacing, and (2) BV programmed electrical stimulation (PES) decreases the induction of ventricular arrhythmias compared with standard RV-PES, regardless of the presence of intraventricular conduction delay. Background. Previous studies have su ggested that BV pacing might decrease the frequency of ventricular arrhythmias; however, the mechanism of arrhythmia suppression remains unclear. Methods. Eighteen patients with coronary artery disease were randomized to RV-PES or BV-PES with a repeat study using the other pacing mode. The RV effective refractory periods were measured during RV-PES and BV-PES. In addition, the local LV S1-S2 coupling interval was measured at 600/450 ms and 400/350 ms during RV-PES and BV-PES. Results. BV-PES had no effect on RV effective refractory periods. On the other hand, the local LV S1-S2 coupling intervals increased significantly during BV-PES compared with RV-PES (P < .0001). Ventricular tachycardia was induced in six patients using RV-PES but in only one patient with BV-PES (RR = 83%, P = .01). No difference was observed in the induction of ventricular fibrillation. Conclusions. BV-PES significantly reduced the induction of ventricular tachycardia compared to RV-PES, with no significant effect on ventricular fibrillation induction. Our findings may help explain the reduced incidence of ventricular arrhythmias noted with chronic BV pacing.

KW - Biventricular pacing

KW - Electrophysiology

KW - Ventricular arrhythmias

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