Black Tea Improves Endothelial Function in Renal Transplant Recipients

M. R. Ardalan, M. K. Tarzamni, Mohammadali Mohajel Shoja, R. S. Tubbs, B. Rahimi-Ardabili, K. Ghabili, H. T. Khosroshahi

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Background: Endothelial damage and dysfunction are commonplace in renal transplant recipients. Impaired endothelial function is an important contributor to cardiovascular diseases. We hypothesized that short-term black tea consumption may improve endothelium-dependent arterial dilation in kidney recipients. Methods: Fifteen recipients were studied on an outpatient basis in a single, university-affiliated clinic. Inclusion criteria were stable and good allograft function. The main exclusion criteria were uncontrolled hypertension, smoking, alcohol consumption, coffee drinking, diabetes mellitus, and coronary artery disease, or a history of upper limb vascular manipulations. After overnight fasting, the brachial artery diameter (BAD) was measured at the end of diastole using an ultrasound machine before (basal BAD) and 1 minute after temporary (∼3 minutes) external occlusion (posthyperemia BAD). Flow-mediated vasodilation (FMV) and percent of FMV (FMV%) were calculated by appropriate formula. FMV and FMV% were determined at baseline and 2 hours after consuming 0.5 L freshly brewed black tea. For control, the study was repeated for each patient the next day and FMV and FMV% were determined before and 2 hours after consuming 0.5 L of water. Results: The men age of patients was 37.2 ± 9.7 years (range, 25 to 50) with a male:female ratio of 3:2. Patients were 26.8 ± 10.6 months postrenal transplantation. Black tea consumption significantly increased posthyperemia BAD, FMV, and FMV% (P < .05). However, water consumption did not alter the basal or posthyperemia BAD, FMV, or FMV% (P > .05). Conclusion: Based on our study, short-term consumption of black tea may improve endothelial function and endothelium-dependent arterial vasodilation in renal transplant recipients.

Original languageEnglish (US)
Pages (from-to)1139-1142
Number of pages4
JournalTransplantation Proceedings
Volume39
Issue number4
DOIs
StatePublished - May 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Ardalan, M. R., Tarzamni, M. K., Mohajel Shoja, M., Tubbs, R. S., Rahimi-Ardabili, B., Ghabili, K., & Khosroshahi, H. T. (2007). Black Tea Improves Endothelial Function in Renal Transplant Recipients. Transplantation Proceedings, 39(4), 1139-1142. https://doi.org/10.1016/j.transproceed.2007.04.010