Blast-like cells in the cerebrospinal fluid of young infants

Further characterization of clinical setting, morphology, and origin

Pamela B. Jaffey, Sudhir K. Varma, Richard M. DeMay, Eddye J. McLucas, Gerald Campbell

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Blast-like cells in the cerebrospinal fluid (CSF) of neonates have been identified and previously suggested to be of germinal matrix origin. Twelve additional CSF specimens with blast-like cells collected at the University of Texas Medical Branch, Galveston, between 1985-1992 were analyzed. The cytological features of the blast-like cells as well as their associated clinical setting were further characterized by the authors. All patients in the study were young infants with hydrocephalus and nearly all underwent placement of a ventriculoperitoneal (VP) shunt at the time the CSF specimen was collected. In addition, a cytologic preparation of germinal matrix cells obtained from an autopsy specimen was analyzed, which closely resembled the blast-like cells. These data provide additional evidence that blast-like cells originate from the germinal matrix.

Original languageEnglish (US)
Pages (from-to)544-547
Number of pages4
JournalAmerican Journal of Clinical Pathology
Volume105
Issue number5
StatePublished - May 1996

Fingerprint

Cerebrospinal Fluid
Ventriculoperitoneal Shunt
Hydrocephalus
Autopsy
Newborn Infant

Keywords

  • Cerebrospinal fluid cytology
  • Germinal matrix cells
  • Hydrocephalus
  • Lymphoblasts
  • Medulloblastoma
  • Ventriculoperitoneal shunt

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Blast-like cells in the cerebrospinal fluid of young infants : Further characterization of clinical setting, morphology, and origin. / Jaffey, Pamela B.; Varma, Sudhir K.; DeMay, Richard M.; McLucas, Eddye J.; Campbell, Gerald.

In: American Journal of Clinical Pathology, Vol. 105, No. 5, 05.1996, p. 544-547.

Research output: Contribution to journalArticle

@article{170f6419b75e4d3eb2095c0f7249968c,
title = "Blast-like cells in the cerebrospinal fluid of young infants: Further characterization of clinical setting, morphology, and origin",
abstract = "Blast-like cells in the cerebrospinal fluid (CSF) of neonates have been identified and previously suggested to be of germinal matrix origin. Twelve additional CSF specimens with blast-like cells collected at the University of Texas Medical Branch, Galveston, between 1985-1992 were analyzed. The cytological features of the blast-like cells as well as their associated clinical setting were further characterized by the authors. All patients in the study were young infants with hydrocephalus and nearly all underwent placement of a ventriculoperitoneal (VP) shunt at the time the CSF specimen was collected. In addition, a cytologic preparation of germinal matrix cells obtained from an autopsy specimen was analyzed, which closely resembled the blast-like cells. These data provide additional evidence that blast-like cells originate from the germinal matrix.",
keywords = "Cerebrospinal fluid cytology, Germinal matrix cells, Hydrocephalus, Lymphoblasts, Medulloblastoma, Ventriculoperitoneal shunt",
author = "Jaffey, {Pamela B.} and Varma, {Sudhir K.} and DeMay, {Richard M.} and McLucas, {Eddye J.} and Gerald Campbell",
year = "1996",
month = "5",
language = "English (US)",
volume = "105",
pages = "544--547",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "5",

}

TY - JOUR

T1 - Blast-like cells in the cerebrospinal fluid of young infants

T2 - Further characterization of clinical setting, morphology, and origin

AU - Jaffey, Pamela B.

AU - Varma, Sudhir K.

AU - DeMay, Richard M.

AU - McLucas, Eddye J.

AU - Campbell, Gerald

PY - 1996/5

Y1 - 1996/5

N2 - Blast-like cells in the cerebrospinal fluid (CSF) of neonates have been identified and previously suggested to be of germinal matrix origin. Twelve additional CSF specimens with blast-like cells collected at the University of Texas Medical Branch, Galveston, between 1985-1992 were analyzed. The cytological features of the blast-like cells as well as their associated clinical setting were further characterized by the authors. All patients in the study were young infants with hydrocephalus and nearly all underwent placement of a ventriculoperitoneal (VP) shunt at the time the CSF specimen was collected. In addition, a cytologic preparation of germinal matrix cells obtained from an autopsy specimen was analyzed, which closely resembled the blast-like cells. These data provide additional evidence that blast-like cells originate from the germinal matrix.

AB - Blast-like cells in the cerebrospinal fluid (CSF) of neonates have been identified and previously suggested to be of germinal matrix origin. Twelve additional CSF specimens with blast-like cells collected at the University of Texas Medical Branch, Galveston, between 1985-1992 were analyzed. The cytological features of the blast-like cells as well as their associated clinical setting were further characterized by the authors. All patients in the study were young infants with hydrocephalus and nearly all underwent placement of a ventriculoperitoneal (VP) shunt at the time the CSF specimen was collected. In addition, a cytologic preparation of germinal matrix cells obtained from an autopsy specimen was analyzed, which closely resembled the blast-like cells. These data provide additional evidence that blast-like cells originate from the germinal matrix.

KW - Cerebrospinal fluid cytology

KW - Germinal matrix cells

KW - Hydrocephalus

KW - Lymphoblasts

KW - Medulloblastoma

KW - Ventriculoperitoneal shunt

UR - http://www.scopus.com/inward/record.url?scp=0029878996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029878996&partnerID=8YFLogxK

M3 - Article

VL - 105

SP - 544

EP - 547

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 5

ER -