Blast-related brain injury

imaging for clinical and research applications: report of the 2008 st. louis workshop

Tammie L S Benzinger, David Brody, Sylvain Cardin, Kenneth C. Curley, Mark A. Mintun, Seong K. Mun, Kenneth H. Wong, Jean R. Wrathall, Regina C. Armstrong, Philip V. Bayly, Timothy B. Bentley, Mikulas Chavko, Maurizio Corbetta, Joseph P. Culver, Douglas Dewitt, Alan I. Faden, Gary Fiskum, Susan M. Fitzpatrick, Thomas Gennarelli, Jamshid Ghajar & 36 others Rao P. Gullapalli, David Hovda, R. Gilbert Jost, Evan D. Kharasch, Karen Kharasch, Patrick Kochanek, Markus Lammle, Michael J. Leggieri, Lawrence L. Latour, Deborah M. Little, Christine L. Mac Donald, Christian Macedonia, Daniel Marcus, Joseph T. McCabe, Richard M. McCarron, David Moore, Pratik Mukherjee, John Povlishock, Joseph Pancrazio, Steve Petersen, Elaine R. Peskind, Kathy J. Pierce, Jose A. Pineda, Murray Raskind, Charles Riedel, David Ritzel, Joshua S. Shimony, Alice Boyd Smith, Douglas H. Smith, James Smirniotopoulos, Victor Sheng Kwei Song, Barbara B. Sterkel, Stanislav Svetlov, Pamela J. VandeVord, Alan W. Young, Gregory Zipfel

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Blast-related traumatic brain injury (bTBI) and post-traumatic stress disorder (PTSD) have been of particular relevance to the military and civilian health care sectors since the onset of the Global War on Terror, and TBI has been called the "signature injury" of this war. Currently there are many questions about the fundamental nature, diagnosis, and long-term consequences of bTBI and its relationship to PTSD. This workshop was organized to consider these questions and focus on how brain imaging techniques may be used to enhance current diagnosis, research, and treatment of bTBI. The general conclusion was that although the study of blast physics in non-biological systems is mature, few data are presently available on key topics such as blast exposure in combat scenarios, the pathological characteristics of human bTBI, and imaging signatures of bTBI. Addressing these gaps is critical to the success of bTBI research. Foremost among our recommendations is that human autopsy and pathoanatomical data from bTBI patients need to be obtained and disseminated to the military and civilian research communities, and advanced neuroimaging used in studies of acute, subacute, and chronic cases, to determine whether there is a distinct pathoanatomical signature that correlates with long-term functional impairment, including PTSD. These data are also critical for the development of animal models to illuminate fundamental mechanisms of bTBI and provide leads for new treatment approaches. Brain imaging will need to play an increasingly important role as gaps in the scientific knowledge of bTBI and PTSD are addressed through increased coordination, cooperation, and data sharing among the academic and military biomedical research communities.

Original languageEnglish (US)
Pages (from-to)2127-2144
Number of pages18
JournalJournal of Neurotrauma
Volume26
Issue number12
DOIs
StatePublished - Dec 1 2009

Fingerprint

Neuroimaging
Brain Injuries
Education
Post-Traumatic Stress Disorders
Research
Traumatic Brain Injury
Health Care Sector
Information Dissemination
Physics
Biomedical Research
Autopsy
Animal Models
Wounds and Injuries
Therapeutics

Keywords

  • Animal models of blast-related injury
  • Blast physics
  • Blast-related traumatic brain injury
  • Brain imaging
  • Post-traumatic stress disorder

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Benzinger, T. L. S., Brody, D., Cardin, S., Curley, K. C., Mintun, M. A., Mun, S. K., ... Zipfel, G. (2009). Blast-related brain injury: imaging for clinical and research applications: report of the 2008 st. louis workshop. Journal of Neurotrauma, 26(12), 2127-2144. https://doi.org/10.1089/neu.2009.0885

Blast-related brain injury : imaging for clinical and research applications: report of the 2008 st. louis workshop. / Benzinger, Tammie L S; Brody, David; Cardin, Sylvain; Curley, Kenneth C.; Mintun, Mark A.; Mun, Seong K.; Wong, Kenneth H.; Wrathall, Jean R.; Armstrong, Regina C.; Bayly, Philip V.; Bentley, Timothy B.; Chavko, Mikulas; Corbetta, Maurizio; Culver, Joseph P.; Dewitt, Douglas; Faden, Alan I.; Fiskum, Gary; Fitzpatrick, Susan M.; Gennarelli, Thomas; Ghajar, Jamshid; Gullapalli, Rao P.; Hovda, David; Jost, R. Gilbert; Kharasch, Evan D.; Kharasch, Karen; Kochanek, Patrick; Lammle, Markus; Leggieri, Michael J.; Latour, Lawrence L.; Little, Deborah M.; Mac Donald, Christine L.; Macedonia, Christian; Marcus, Daniel; McCabe, Joseph T.; McCarron, Richard M.; Moore, David; Mukherjee, Pratik; Povlishock, John; Pancrazio, Joseph; Petersen, Steve; Peskind, Elaine R.; Pierce, Kathy J.; Pineda, Jose A.; Raskind, Murray; Riedel, Charles; Ritzel, David; Shimony, Joshua S.; Smith, Alice Boyd; Smith, Douglas H.; Smirniotopoulos, James; Song, Victor Sheng Kwei; Sterkel, Barbara B.; Svetlov, Stanislav; VandeVord, Pamela J.; Young, Alan W.; Zipfel, Gregory.

In: Journal of Neurotrauma, Vol. 26, No. 12, 01.12.2009, p. 2127-2144.

Research output: Contribution to journalArticle

Benzinger, TLS, Brody, D, Cardin, S, Curley, KC, Mintun, MA, Mun, SK, Wong, KH, Wrathall, JR, Armstrong, RC, Bayly, PV, Bentley, TB, Chavko, M, Corbetta, M, Culver, JP, Dewitt, D, Faden, AI, Fiskum, G, Fitzpatrick, SM, Gennarelli, T, Ghajar, J, Gullapalli, RP, Hovda, D, Jost, RG, Kharasch, ED, Kharasch, K, Kochanek, P, Lammle, M, Leggieri, MJ, Latour, LL, Little, DM, Mac Donald, CL, Macedonia, C, Marcus, D, McCabe, JT, McCarron, RM, Moore, D, Mukherjee, P, Povlishock, J, Pancrazio, J, Petersen, S, Peskind, ER, Pierce, KJ, Pineda, JA, Raskind, M, Riedel, C, Ritzel, D, Shimony, JS, Smith, AB, Smith, DH, Smirniotopoulos, J, Song, VSK, Sterkel, BB, Svetlov, S, VandeVord, PJ, Young, AW & Zipfel, G 2009, 'Blast-related brain injury: imaging for clinical and research applications: report of the 2008 st. louis workshop', Journal of Neurotrauma, vol. 26, no. 12, pp. 2127-2144. https://doi.org/10.1089/neu.2009.0885
Benzinger, Tammie L S ; Brody, David ; Cardin, Sylvain ; Curley, Kenneth C. ; Mintun, Mark A. ; Mun, Seong K. ; Wong, Kenneth H. ; Wrathall, Jean R. ; Armstrong, Regina C. ; Bayly, Philip V. ; Bentley, Timothy B. ; Chavko, Mikulas ; Corbetta, Maurizio ; Culver, Joseph P. ; Dewitt, Douglas ; Faden, Alan I. ; Fiskum, Gary ; Fitzpatrick, Susan M. ; Gennarelli, Thomas ; Ghajar, Jamshid ; Gullapalli, Rao P. ; Hovda, David ; Jost, R. Gilbert ; Kharasch, Evan D. ; Kharasch, Karen ; Kochanek, Patrick ; Lammle, Markus ; Leggieri, Michael J. ; Latour, Lawrence L. ; Little, Deborah M. ; Mac Donald, Christine L. ; Macedonia, Christian ; Marcus, Daniel ; McCabe, Joseph T. ; McCarron, Richard M. ; Moore, David ; Mukherjee, Pratik ; Povlishock, John ; Pancrazio, Joseph ; Petersen, Steve ; Peskind, Elaine R. ; Pierce, Kathy J. ; Pineda, Jose A. ; Raskind, Murray ; Riedel, Charles ; Ritzel, David ; Shimony, Joshua S. ; Smith, Alice Boyd ; Smith, Douglas H. ; Smirniotopoulos, James ; Song, Victor Sheng Kwei ; Sterkel, Barbara B. ; Svetlov, Stanislav ; VandeVord, Pamela J. ; Young, Alan W. ; Zipfel, Gregory. / Blast-related brain injury : imaging for clinical and research applications: report of the 2008 st. louis workshop. In: Journal of Neurotrauma. 2009 ; Vol. 26, No. 12. pp. 2127-2144.
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