Block of kainate receptor channels by Ca2+ in isolated spinal trigeminal neurons of rat

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    42 Scopus citations

    Abstract

    Compared with N-methyl-aspartate-activated channels, the interaction of Ca2+ with kainate-activated or with quisqualate-activated channels is not well understood. We have studied the effect of Ca2+ on kainate-activated currents in isolated trigeminal neurons and found that Ca2+ inhibits kainate responses. This inhibition occurs not because Ca2+ changes the affinity of kainate to its receptor, but because Ca2+ blocks monovalent cation permeation through kainate-activated channels. This Ca2+ block gives rise to the outward rectification of the kainate responses.

    Original languageEnglish (US)
    Pages (from-to)777-784
    Number of pages8
    JournalNeuron
    Volume6
    Issue number5
    DOIs
    StatePublished - May 1991

    ASJC Scopus subject areas

    • General Neuroscience

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