Blocking of exchange proteins directly activated by cAMP leads to reduced replication of middle east respiratory syndrome coronavirus

Xinrong Tao, Feng Mei, Anurodh Agrawal, Clarence J. Peters, Thomas Ksiazek, Xiaodong Cheng, Chien-Te Tseng

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infections and diseases represents a potential threat for worldwide spread and requires development of effective therapeutic strategies. In this study, we revealed a novel positive function of an exchange protein directly activated by cyclic AMP 1 (cAMP-1; Epac-1) on MERS-CoV replication. Specifically, we have shown that Epac-specific inhibitor treatment or silencing Epac-1 gene expression rendered cells resistant to viral infection. We believe Epac-1 inhibitors deserve further study as potential therapeutic agents for MERS-CoV infection.

Original languageEnglish (US)
Pages (from-to)3902-3910
Number of pages9
JournalJournal of Virology
Volume88
Issue number7
DOIs
StatePublished - 2014

Fingerprint

Coronavirus Infections
infection
therapeutics
Proteins
proteins
cyclic AMP
Virus Diseases
Cyclic AMP
Disease Outbreaks
Gene Expression
gene expression
Therapeutics
Middle East Respiratory Syndrome Coronavirus
Middle East respiratory syndrome coronavirus
cells

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Blocking of exchange proteins directly activated by cAMP leads to reduced replication of middle east respiratory syndrome coronavirus. / Tao, Xinrong; Mei, Feng; Agrawal, Anurodh; Peters, Clarence J.; Ksiazek, Thomas; Cheng, Xiaodong; Tseng, Chien-Te.

In: Journal of Virology, Vol. 88, No. 7, 2014, p. 3902-3910.

Research output: Contribution to journalArticle

Tao, Xinrong ; Mei, Feng ; Agrawal, Anurodh ; Peters, Clarence J. ; Ksiazek, Thomas ; Cheng, Xiaodong ; Tseng, Chien-Te. / Blocking of exchange proteins directly activated by cAMP leads to reduced replication of middle east respiratory syndrome coronavirus. In: Journal of Virology. 2014 ; Vol. 88, No. 7. pp. 3902-3910.
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