TY - JOUR
T1 - Blood-brain barrier permeability in the ischemic stroke
T2 - An update
AU - Mathias, Khiany
AU - Machado, Richard Simon
AU - Stork, Solange
AU - dos Santos, David
AU - Joaquim, Larissa
AU - Generoso, Jaqueline
AU - Danielski, Lucinéia Gainski
AU - Barichello, Tatiana
AU - Prophiro, Josiane Somariva
AU - Petronilho, Fabricia
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2024/1
Y1 - 2024/1
N2 - Stroke is the second leading cause of death globally and the major cause of long-term disability. Among the types of strokes, ischemic stroke, which occurs due to obstruction of blood vessels responsible for cerebral irrigation, is considered the most prevalent, accounting for approximately 86 % of all stroke cases. This interruption of blood supply leads to a critical pathophysiological mechanism, including oxidative stress and neuroinflammation which are responsible for structural alterations of the blood-brain barrier (BBB). The increased BBB permeability associated with cerebral ischemia-reperfusion may contribute to a worse outcome after stroke. Thus, this narrative review aims to update the pathophysiological mechanisms involved in the increase in BBB permeability and to list the possible therapeutic strategies.
AB - Stroke is the second leading cause of death globally and the major cause of long-term disability. Among the types of strokes, ischemic stroke, which occurs due to obstruction of blood vessels responsible for cerebral irrigation, is considered the most prevalent, accounting for approximately 86 % of all stroke cases. This interruption of blood supply leads to a critical pathophysiological mechanism, including oxidative stress and neuroinflammation which are responsible for structural alterations of the blood-brain barrier (BBB). The increased BBB permeability associated with cerebral ischemia-reperfusion may contribute to a worse outcome after stroke. Thus, this narrative review aims to update the pathophysiological mechanisms involved in the increase in BBB permeability and to list the possible therapeutic strategies.
KW - Blood-brain barrier
KW - Ischemic stroke
KW - Neuroinflammation
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U2 - 10.1016/j.mvr.2023.104621
DO - 10.1016/j.mvr.2023.104621
M3 - Review article
C2 - 37918521
AN - SCOPUS:85178203674
SN - 0026-2862
VL - 151
JO - Microvascular research
JF - Microvascular research
M1 - 104621
ER -