Blood-brain barrier permeability in the ischemic stroke: An update

Khiany Mathias, Richard Simon Machado, Solange Stork, David dos Santos, Larissa Joaquim, Jaqueline Generoso, Lucinéia Gainski Danielski, Tatiana Barichello, Josiane Somariva Prophiro, Fabricia Petronilho

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Stroke is the second leading cause of death globally and the major cause of long-term disability. Among the types of strokes, ischemic stroke, which occurs due to obstruction of blood vessels responsible for cerebral irrigation, is considered the most prevalent, accounting for approximately 86 % of all stroke cases. This interruption of blood supply leads to a critical pathophysiological mechanism, including oxidative stress and neuroinflammation which are responsible for structural alterations of the blood-brain barrier (BBB). The increased BBB permeability associated with cerebral ischemia-reperfusion may contribute to a worse outcome after stroke. Thus, this narrative review aims to update the pathophysiological mechanisms involved in the increase in BBB permeability and to list the possible therapeutic strategies.

Original languageEnglish (US)
Article number104621
JournalMicrovascular research
Volume151
DOIs
StatePublished - Jan 2024
Externally publishedYes

Keywords

  • Blood-brain barrier
  • Ischemic stroke
  • Neuroinflammation

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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