Blood-brain barrier permeability: Quantification with computed tomography and application in acute ischemic stroke

M. Wintermark; J. Hom; J. W. Dankbaar; J. Bredno; M. E. Olszewski

Blood-brain barrier permeability: Quantification with computed tomography and application in acute ischemic stroke

M. Wintermark
, J. Hom
, J. W. Dankbaar
, J. Bredno
, M. E. Olszewski

Research output: Contribution to journal › Article › peer-review

Abstract

Given the high costs - human and financial - associated with stroke and its aftermath, improvements to stroke treatment are of paramount importance. Recombinant tissue plasminogen activator (rt-TPA) has been shown to be effective in treating acute ischemic stroke; however, rt-TPA is currently only approved for use within a fixed time window, and it is associated with a non-negligible risk of hemorrhagic transformation. This article describes quantitative CT imaging of blood-brain barrier permeability that may enable a more widespread administration of rt-TPA in acute stroke by allowing risk-balanced, individualized treatment decisions that are based on physiology rather than time.

Original language	English (US)
Pages (from-to)	3-8+63+65+67+69
Journal	MedicaMundi
Volume	53
Issue number	2
State	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Cite this

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AU - Hom, J.

AU - Dankbaar, J. W.

AU - Bredno, J.

AU - Olszewski, M. E.

PY - 2009

Y1 - 2009

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AB - Given the high costs - human and financial - associated with stroke and its aftermath, improvements to stroke treatment are of paramount importance. Recombinant tissue plasminogen activator (rt-TPA) has been shown to be effective in treating acute ischemic stroke; however, rt-TPA is currently only approved for use within a fixed time window, and it is associated with a non-negligible risk of hemorrhagic transformation. This article describes quantitative CT imaging of blood-brain barrier permeability that may enable a more widespread administration of rt-TPA in acute stroke by allowing risk-balanced, individualized treatment decisions that are based on physiology rather than time.

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IS - 2

ER -

Blood-brain barrier permeability: Quantification with computed tomography and application in acute ischemic stroke

Abstract

ASJC Scopus subject areas

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