Blood phenylalanine levels and intelligence of 10-year-old children with PKU in the National Collaborative Study

K. Michals, C. Azen, P. Acosta, R. Koch, Reuben Matalon

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Dietary intakes and blood phenylalanine levels of 125 10-year-old children with PKU are reported. Of those patients, 59 discontinued the special diet at 6 years, 16 discontinued at 8 years, 5 discontinued at 6 years but returned to the diet at 8 1/2 years, and 45 continued the diet to 10 years. Phenylalanine intake was determined by 2-day diet records. Blood phenylalanine concentrations revealed a lack of clear distinction between the diet groups; therefore, regression analysis was performed on the group as a whole. The analyses revealed significant relationships between blood phenylalanine levels from ages 6 to 10 years and each of the cognitive outcome variables, after the influences of parental IQ and the age at which treatment was initiated were controlled for. Intelligence test scores were also related to phenylalanine levels between ages 3 1/2 and 5 1/2 years. The findings suggest that dietary restriction of phenylalanine should continue in patients with PKU through at least 10 years of age.

Original languageEnglish (US)
Pages (from-to)1226-1229
Number of pages4
JournalJournal of the American Dietetic Association
Volume88
Issue number10
StatePublished - 1988
Externally publishedYes

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Phenylalanine
Intelligence
phenylalanine
blood
Diet
diet
special diets
Diet Records
dietary restriction
Intelligence Tests
food intake
regression analysis
Parents
Regression Analysis
testing

ASJC Scopus subject areas

  • Food Science
  • Medicine(all)

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Blood phenylalanine levels and intelligence of 10-year-old children with PKU in the National Collaborative Study. / Michals, K.; Azen, C.; Acosta, P.; Koch, R.; Matalon, Reuben.

In: Journal of the American Dietetic Association, Vol. 88, No. 10, 1988, p. 1226-1229.

Research output: Contribution to journalArticle

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