Abstract
Background: Major trauma and burns are associated with whole body catabolism which can persist for 1 or more years after injury. This study investigates body composition in massively burned children for up to 2 years. Methods: Twenty-five pediatric patients with greater than 40% total body surface area burns were studied. At discharge, 6, 12, 18, and 24 months after burn height, weight, body composition, resting energy expenditure (REE), serum growth hormone, insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), insulin, cortisol, parathyroid hormone, and thyroid hormones were measured. Tukey's test was used for analysis. Significance was accepted at p < 0.05. Results: Lean body mass, fat mass, bone mineral content, height, and weight increased significantly during the second year after burn. Percent predicted REE decreased significantly, whereas IGFBP-3 and parathyroid hormone levels increased significantly over time. Insulin and T3 uptake were significantly higher at discharge. Conclusions: Body composition of severely burned children significantly improved in the second year compared with the first year after injury. This demonstrates a need for long-term rehabilitation in these burn patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 968-971 |
| Number of pages | 4 |
| Journal | Journal of Trauma - Injury, Infection and Critical Care |
| Volume | 60 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2006 |
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Keywords
- Body composition
- Bone mineral content
- Bone mineral density
- Catabolism
- Height
- Hormones
- Hypermetabolism
- Lean body mass
- Pediatric burns
- Weight
ASJC Scopus subject areas
- Surgery
Cite this
Body composition changes with time in pediatric burn patients. / Przkora, Rene; Barrow, Robert E.; Jeschke, Marc G.; Suman, Oscar; Celis, Mario; Sanford, Arthur P.; Chinkes, David L.; Mlcak, Ronald P.; Herndon, David.
In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 60, No. 5, 05.2006, p. 968-971.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Body composition changes with time in pediatric burn patients
AU - Przkora, Rene
AU - Barrow, Robert E.
AU - Jeschke, Marc G.
AU - Suman, Oscar
AU - Celis, Mario
AU - Sanford, Arthur P.
AU - Chinkes, David L.
AU - Mlcak, Ronald P.
AU - Herndon, David
PY - 2006/5
Y1 - 2006/5
N2 - Background: Major trauma and burns are associated with whole body catabolism which can persist for 1 or more years after injury. This study investigates body composition in massively burned children for up to 2 years. Methods: Twenty-five pediatric patients with greater than 40% total body surface area burns were studied. At discharge, 6, 12, 18, and 24 months after burn height, weight, body composition, resting energy expenditure (REE), serum growth hormone, insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), insulin, cortisol, parathyroid hormone, and thyroid hormones were measured. Tukey's test was used for analysis. Significance was accepted at p < 0.05. Results: Lean body mass, fat mass, bone mineral content, height, and weight increased significantly during the second year after burn. Percent predicted REE decreased significantly, whereas IGFBP-3 and parathyroid hormone levels increased significantly over time. Insulin and T3 uptake were significantly higher at discharge. Conclusions: Body composition of severely burned children significantly improved in the second year compared with the first year after injury. This demonstrates a need for long-term rehabilitation in these burn patients.
AB - Background: Major trauma and burns are associated with whole body catabolism which can persist for 1 or more years after injury. This study investigates body composition in massively burned children for up to 2 years. Methods: Twenty-five pediatric patients with greater than 40% total body surface area burns were studied. At discharge, 6, 12, 18, and 24 months after burn height, weight, body composition, resting energy expenditure (REE), serum growth hormone, insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), insulin, cortisol, parathyroid hormone, and thyroid hormones were measured. Tukey's test was used for analysis. Significance was accepted at p < 0.05. Results: Lean body mass, fat mass, bone mineral content, height, and weight increased significantly during the second year after burn. Percent predicted REE decreased significantly, whereas IGFBP-3 and parathyroid hormone levels increased significantly over time. Insulin and T3 uptake were significantly higher at discharge. Conclusions: Body composition of severely burned children significantly improved in the second year compared with the first year after injury. This demonstrates a need for long-term rehabilitation in these burn patients.
KW - Body composition
KW - Bone mineral content
KW - Bone mineral density
KW - Catabolism
KW - Height
KW - Hormones
KW - Hypermetabolism
KW - Lean body mass
KW - Pediatric burns
KW - Weight
UR - http://www.scopus.com/inward/record.url?scp=33646876171&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646876171&partnerID=8YFLogxK
U2 - 10.1097/01.ta.0000214580.27501.19
DO - 10.1097/01.ta.0000214580.27501.19
M3 - Article
VL - 60
SP - 968
EP - 971
JO - Journal of Trauma and Acute Care Surgery
JF - Journal of Trauma and Acute Care Surgery
SN - 2163-0755
IS - 5
ER -