Bombesin stimulates growth of colon cancer in mice and decreases their survival

A. Farre, J. Ishizuka, G. Gomez, D. Parekh, J. Y. Koo, C. M. Townsend, J. C. Thompson

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Bombesin (BBS) stimulates cellular proliferation of both normal and transformed cells. The mouse colon cancer cells (MC-26) possess specific binding sites for BBS. The purpose of this study, therefore, was to examine the effect of chronic administration of BBS on in vivo growth of MC-26 tumours in Balb/c mice and on survival of tumour-bearing mice. Three groups of mice (n = 10 each) inoculated with MC-26 cells received either saline containing 0.1% bovine serum albumin (BSA), or BBS (5 μg kg-1 or 20 μg kg-1) dissolved with 0.1% BSA saline by intraperitoneal route three times a day for 15 days. BBS increased weight, DNA and RNA contents of MC-26 tumours. To examine the effect of BBS on suŕvival rates of mice with MC-26 tumours, three groups of mice (n = 20 each) were treated for 31 days, as above. Onc group of mice inoculated with MC-26 cells received 0.1% BSA saline; the other group of MC-26-inoculated mice and the control group without tumour received BBS (5 μg kg-1) dissolved with 0.1% BSA saline. BBS significantly decreased the survival rate of mice bearing MC-26 tumours (median survival; saline group: 42.5 days, BBS group: 32.0 days, p = 0.037). None of the mice in the control group died during the experiment. BBS may stimulate in vivo growth of MC-26 cells through specific receptors.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalSurgical oncology
Volume2
Issue number3
DOIs
StatePublished - 1993

Keywords

  • adenocarcinoma
  • bombesin
  • colon
  • growth
  • mice
  • survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

Fingerprint Dive into the research topics of 'Bombesin stimulates growth of colon cancer in mice and decreases their survival'. Together they form a unique fingerprint.

  • Cite this

    Farre, A., Ishizuka, J., Gomez, G., Parekh, D., Koo, J. Y., Townsend, C. M., & Thompson, J. C. (1993). Bombesin stimulates growth of colon cancer in mice and decreases their survival. Surgical oncology, 2(3), 169-173. https://doi.org/10.1016/0960-7404(93)90004-I