Bombesin stimulates growth of colon cancer in mice and decreases their survival

A. Farre, J. Ishizuka, Guillermo Gomez, D. Parekh, J. Y. Koo, Courtney Townsend, J. C. Thompson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Bombesin (BBS) stimulates cellular proliferation of both normal and transformed cells. The mouse colon cancer cells (MC-26) possess specific binding sites for BBS. The purpose of this study, therefore, was to examine the effect of chronic administration of BBS on in vivo growth of MC-26 tumours in Balb/c mice and on survival of tumour-bearing mice. Three groups of mice (n = 10 each) inoculated with MC-26 cells received either saline containing 0.1% bovine serum albumin (BSA), or BBS (5 μg kg-1 or 20 μg kg-1) dissolved with 0.1% BSA saline by intraperitoneal route three times a day for 15 days. BBS increased weight, DNA and RNA contents of MC-26 tumours. To examine the effect of BBS on suŕvival rates of mice with MC-26 tumours, three groups of mice (n = 20 each) were treated for 31 days, as above. Onc group of mice inoculated with MC-26 cells received 0.1% BSA saline; the other group of MC-26-inoculated mice and the control group without tumour received BBS (5 μg kg-1) dissolved with 0.1% BSA saline. BBS significantly decreased the survival rate of mice bearing MC-26 tumours (median survival; saline group: 42.5 days, BBS group: 32.0 days, p = 0.037). None of the mice in the control group died during the experiment. BBS may stimulate in vivo growth of MC-26 cells through specific receptors.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalSurgical Oncology
Volume2
Issue number3
DOIs
StatePublished - 1993

Fingerprint

Bombesin
Colonic Neoplasms
Growth
Bovine Serum Albumin
Neoplasms
Control Groups
Binding Sites
Cell Proliferation
RNA
Weights and Measures

Keywords

  • adenocarcinoma
  • bombesin
  • colon
  • growth
  • mice
  • survival

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Farre, A., Ishizuka, J., Gomez, G., Parekh, D., Koo, J. Y., Townsend, C., & Thompson, J. C. (1993). Bombesin stimulates growth of colon cancer in mice and decreases their survival. Surgical Oncology, 2(3), 169-173. https://doi.org/10.1016/0960-7404(93)90004-I

Bombesin stimulates growth of colon cancer in mice and decreases their survival. / Farre, A.; Ishizuka, J.; Gomez, Guillermo; Parekh, D.; Koo, J. Y.; Townsend, Courtney; Thompson, J. C.

In: Surgical Oncology, Vol. 2, No. 3, 1993, p. 169-173.

Research output: Contribution to journalArticle

Farre, A, Ishizuka, J, Gomez, G, Parekh, D, Koo, JY, Townsend, C & Thompson, JC 1993, 'Bombesin stimulates growth of colon cancer in mice and decreases their survival', Surgical Oncology, vol. 2, no. 3, pp. 169-173. https://doi.org/10.1016/0960-7404(93)90004-I
Farre, A. ; Ishizuka, J. ; Gomez, Guillermo ; Parekh, D. ; Koo, J. Y. ; Townsend, Courtney ; Thompson, J. C. / Bombesin stimulates growth of colon cancer in mice and decreases their survival. In: Surgical Oncology. 1993 ; Vol. 2, No. 3. pp. 169-173.
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