Bone tissue engineering techniques, advances, and scaffolds for treatment of bone defects

Matthew Alonzo, Fabian Alvarez Primo, Shweta Anil Kumar, Joel A. Mudloff, Erick Dominguez, Gisel Fregoso, Nick Ortiz, William M. Weiss, Binata Joddar

Research output: Contribution to journalReview articlepeer-review

99 Scopus citations


Bone tissue engineering (BTE) aims to develop strategies to regenerate damaged or diseased bone using a combination of cells, growth factors, and biomaterials. This article highlights recent advances in BTE, with particular emphasis on the role of the biomaterials as scaffolding material to heal bone defects. Studies encompass the utilization of bioceramics, composites, and myriad hydrogels that have been fashioned by injection molding, electrospinning, and 3D bioprinting over recent years, with the aim to provide an insight into the progress of BTE along with a commentary on their scope and possibilities to aid future research. The biocompatibility and structural efficacy of some of these biomaterials are also discussed.

Original languageEnglish (US)
Article number100248
JournalCurrent Opinion in Biomedical Engineering
StatePublished - Mar 2021
Externally publishedYes


  • 3D printing
  • Bone defect
  • Electrospinning
  • Injection molding
  • Orthopedics
  • Tissue engineering

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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