Bone tissue engineering techniques, advances, and scaffolds for treatment of bone defects

Matthew Alonzo; Fabian Alvarez Primo; Shweta Anil Kumar; Joel A. Mudloff; Erick Dominguez; Gisel Fregoso; Nick Ortiz; William M. Weiss; Binata Joddar

doi:10.1016/j.cobme.2020.100248

Bone tissue engineering techniques, advances, and scaffolds for treatment of bone defects

Matthew Alonzo, Fabian Alvarez Primo, Shweta Anil Kumar, Joel A. Mudloff, Erick Dominguez, Gisel Fregoso, Nick Ortiz, William M. Weiss, Binata Joddar

Research output: Contribution to journal › Review article › peer-review

186 Scopus citations

Abstract

Bone tissue engineering (BTE) aims to develop strategies to regenerate damaged or diseased bone using a combination of cells, growth factors, and biomaterials. This article highlights recent advances in BTE, with particular emphasis on the role of the biomaterials as scaffolding material to heal bone defects. Studies encompass the utilization of bioceramics, composites, and myriad hydrogels that have been fashioned by injection molding, electrospinning, and 3D bioprinting over recent years, with the aim to provide an insight into the progress of BTE along with a commentary on their scope and possibilities to aid future research. The biocompatibility and structural efficacy of some of these biomaterials are also discussed.

Original language	English (US)
Article number	100248
Journal	Current Opinion in Biomedical Engineering
Volume	17
DOIs	https://doi.org/10.1016/j.cobme.2020.100248
State	Published - Mar 2021
Externally published	Yes

Keywords

3D printing
Bone defect
Electrospinning
Injection molding
Orthopedics
Tissue engineering

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

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10.1016/j.cobme.2020.100248

Cite this

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title = "Bone tissue engineering techniques, advances, and scaffolds for treatment of bone defects",

abstract = "Bone tissue engineering (BTE) aims to develop strategies to regenerate damaged or diseased bone using a combination of cells, growth factors, and biomaterials. This article highlights recent advances in BTE, with particular emphasis on the role of the biomaterials as scaffolding material to heal bone defects. Studies encompass the utilization of bioceramics, composites, and myriad hydrogels that have been fashioned by injection molding, electrospinning, and 3D bioprinting over recent years, with the aim to provide an insight into the progress of BTE along with a commentary on their scope and possibilities to aid future research. The biocompatibility and structural efficacy of some of these biomaterials are also discussed.",

keywords = "3D printing, Bone defect, Electrospinning, Injection molding, Orthopedics, Tissue engineering",

author = "Matthew Alonzo and {Alvarez Primo}, Fabian and {Anil Kumar}, Shweta and Mudloff, {Joel A.} and Erick Dominguez and Gisel Fregoso and Nick Ortiz and Weiss, {William M.} and Binata Joddar",

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year = "2021",

month = mar,

doi = "10.1016/j.cobme.2020.100248",

language = "English (US)",

volume = "17",

journal = "Current Opinion in Biomedical Engineering",

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T1 - Bone tissue engineering techniques, advances, and scaffolds for treatment of bone defects

AU - Alonzo, Matthew

AU - Alvarez Primo, Fabian

AU - Anil Kumar, Shweta

AU - Mudloff, Joel A.

AU - Dominguez, Erick

AU - Fregoso, Gisel

AU - Ortiz, Nick

AU - Weiss, William M.

AU - Joddar, Binata

PY - 2021/3

Y1 - 2021/3

N2 - Bone tissue engineering (BTE) aims to develop strategies to regenerate damaged or diseased bone using a combination of cells, growth factors, and biomaterials. This article highlights recent advances in BTE, with particular emphasis on the role of the biomaterials as scaffolding material to heal bone defects. Studies encompass the utilization of bioceramics, composites, and myriad hydrogels that have been fashioned by injection molding, electrospinning, and 3D bioprinting over recent years, with the aim to provide an insight into the progress of BTE along with a commentary on their scope and possibilities to aid future research. The biocompatibility and structural efficacy of some of these biomaterials are also discussed.

AB - Bone tissue engineering (BTE) aims to develop strategies to regenerate damaged or diseased bone using a combination of cells, growth factors, and biomaterials. This article highlights recent advances in BTE, with particular emphasis on the role of the biomaterials as scaffolding material to heal bone defects. Studies encompass the utilization of bioceramics, composites, and myriad hydrogels that have been fashioned by injection molding, electrospinning, and 3D bioprinting over recent years, with the aim to provide an insight into the progress of BTE along with a commentary on their scope and possibilities to aid future research. The biocompatibility and structural efficacy of some of these biomaterials are also discussed.

KW - 3D printing

KW - Bone defect

KW - Electrospinning

KW - Injection molding

KW - Orthopedics

KW - Tissue engineering

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DO - 10.1016/j.cobme.2020.100248

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JO - Current Opinion in Biomedical Engineering

JF - Current Opinion in Biomedical Engineering

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Bone tissue engineering techniques, advances, and scaffolds for treatment of bone defects

Abstract

Keywords

ASJC Scopus subject areas

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