Both dermal matrix and epidermis contribute to an inhibition of wound contraction

J. L. Walden, H. Garcia, H. Hawkins, J. R. Crouchet, L. Traber, Dennis Gore

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Contracture is a major detriment to functional recovery from large wounds. To determine the relative value of dermal replacement and epidermal coverage in inhibiting wound contraction, five full-thickness wounds (all 5 x 5 cm2) were placed on the back of 8 swine and treated in the following manner: (1) open wound, (2) porcine acellular dermis (analogous to AlloDerm for human use), (3) porcine acellular dermis with epidermal autograft placed 7 days postwounding, (4) porcine acellular dermis with immediate epidermal autograft, and (5) conventional-thickness autograft. Scar dimensions and punch biopsies were taken at days 14 and 30 postwounding. The planimetry results demonstrated that wound contraction was significantly greater with the open wounds (group 1) than all other wounds with a dermal substitute. Furthermore, wounds with initial epidermal coverage had significantly less contraction than unepithelialized wounds (14.8 ± 1.1 cm2 at day 14 in wound group 2 vs. 20.4 ± 0.6 cm2 in wound group 4; p < 0.05). Biopsy results revealed that wounds with initial epithelial coverage had the least amount of inflammation. These findings suggest that both dermal matrix and epidermal coverage contribute to an inhibition of wound contraction and that prompt epithelial coverage appears to impede contraction by reducing inflammation.

Original languageEnglish (US)
Pages (from-to)162-166
Number of pages5
JournalAnnals of Plastic Surgery
Volume45
Issue number2
StatePublished - 2000

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Epidermis
Skin
Wounds and Injuries
Acellular Dermis
Autografts
Swine
Artificial Skin
Inflammation
Biopsy
Contracture
Cicatrix

ASJC Scopus subject areas

  • Surgery

Cite this

Walden, J. L., Garcia, H., Hawkins, H., Crouchet, J. R., Traber, L., & Gore, D. (2000). Both dermal matrix and epidermis contribute to an inhibition of wound contraction. Annals of Plastic Surgery, 45(2), 162-166.

Both dermal matrix and epidermis contribute to an inhibition of wound contraction. / Walden, J. L.; Garcia, H.; Hawkins, H.; Crouchet, J. R.; Traber, L.; Gore, Dennis.

In: Annals of Plastic Surgery, Vol. 45, No. 2, 2000, p. 162-166.

Research output: Contribution to journalArticle

Walden, JL, Garcia, H, Hawkins, H, Crouchet, JR, Traber, L & Gore, D 2000, 'Both dermal matrix and epidermis contribute to an inhibition of wound contraction', Annals of Plastic Surgery, vol. 45, no. 2, pp. 162-166.
Walden JL, Garcia H, Hawkins H, Crouchet JR, Traber L, Gore D. Both dermal matrix and epidermis contribute to an inhibition of wound contraction. Annals of Plastic Surgery. 2000;45(2):162-166.
Walden, J. L. ; Garcia, H. ; Hawkins, H. ; Crouchet, J. R. ; Traber, L. ; Gore, Dennis. / Both dermal matrix and epidermis contribute to an inhibition of wound contraction. In: Annals of Plastic Surgery. 2000 ; Vol. 45, No. 2. pp. 162-166.
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