Both motor and sensory abnormalities contribute to changes in foot posture in an experimental rat neuropathic model

Heung Sik Na, Young Wook Yoon, Jin Chung

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This study was undertaken to find out whether pain contributes to abnormal posture of the foot in rats displaying neuropathic pain behaviors, and if so, whether there is a specific abnormality which reflects the level of pain. We used a rat model of neuropathic pain which is produced by tightly gating the L5 and L6 spinal nerves just distal to the dorsal root ganglion (DRG). The operation produced neuropathic pain behaviors along with abnormal foot posture as has been shown previously. On the other hand, injury to the same somatic sensory and motor fibers at a more proximal site by sectioning dorsal and ventral roots of the same segments did not produce neuropathic pain behaviors. Rats with dorsal and ventral rhizotomies showed an abnormality of foot posture despite the absence of neuropathic pain behaviors. However, the abnormality in these rats was less severe and lasted for a shorter period of time as compared to rats with spinal nerve ligation. This suggests that peripheral nerve injury in our rat neuropathic pain model produces a foot postural abnormality partially due to motor deficit. However, there is an additional component of the abnormality that is related to sensory function, possibly pain. Close examination of the data indicate that there is no single obvious abnormal foot posture which exclusively represents motor deficit or sensory abnormality. Rather, neuropathic rats are likely to display abnormal foot posture as a result of a complex mixture of motor and sensory abnormalities.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalPain
Volume67
Issue number1
DOIs
StatePublished - Sep 1996

Fingerprint

Posture
Neuralgia
Foot
Spinal Nerves
Spinal Nerve Roots
Pain
Rhizotomy
Hand Injuries
Peripheral Nerve Injuries
Spinal Ganglia
Complex Mixtures
Ligation

Keywords

  • Causalgia
  • Hyperalgesia
  • Mechanical allodynia
  • Peripheral nerve injury
  • Sympathetically maintained pain

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Neuroscience(all)
  • Pharmacology
  • Clinical Psychology

Cite this

Both motor and sensory abnormalities contribute to changes in foot posture in an experimental rat neuropathic model. / Na, Heung Sik; Yoon, Young Wook; Chung, Jin.

In: Pain, Vol. 67, No. 1, 09.1996, p. 173-178.

Research output: Contribution to journalArticle

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