Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome

J. L. Jorizzo, P. Apisarnthanarax, P. Subrt, A. A. Hebert, J. C. Henry, Sharon Raimer, S. M. Dinehart, J. A. Reinarz

Research output: Contribution to journalArticle

Abstract

A recurrent, episodic illness that occurs in as many as 20% of patients who undergo ileojejunal bypass surgery for morbid obesity has been well characterized and includes inflammatory cutaneous lesions with a histologic appearance like that of neutrophillic vasculitis, a nondeforming polyarthritis, and other systemic manifestations. Current concepts of pathogenesis center on overgrowth of bacterial flora in the bypassed bowel segment with subsequent development of a circulating immune complex disease. We report, for the first time to our knowledge, an identical clinicopathologic syndrome in four patients who have not had jejunoileal bypass surgery. Each patient, however, had other gastrointestinal disease that we believe predisposed to this syndrome, possibly via circulating immune complexes with bowel-associated antigens. We propose the expanded term, bowel-associated dermatosis-arthritis syndrome, to incorporate these new cases. We believe that this is not a rare syndrome and that it is easily distinguishable from other types of cutaneous necrotizing vasculitis.

Original languageEnglish (US)
Pages (from-to)457-461
Number of pages5
JournalArchives of Internal Medicine
Volume143
Issue number3
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Skin Diseases
Arthritis
Jejunoileal Bypass
Vasculitis
Immune Complex Diseases
Skin
Morbid Obesity
Gastrointestinal Diseases
Antigen-Antibody Complex
Antigens

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Jorizzo, J. L., Apisarnthanarax, P., Subrt, P., Hebert, A. A., Henry, J. C., Raimer, S., ... Reinarz, J. A. (1983). Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome. Archives of Internal Medicine, 143(3), 457-461. https://doi.org/10.1001/archinte.143.3.457

Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome. / Jorizzo, J. L.; Apisarnthanarax, P.; Subrt, P.; Hebert, A. A.; Henry, J. C.; Raimer, Sharon; Dinehart, S. M.; Reinarz, J. A.

In: Archives of Internal Medicine, Vol. 143, No. 3, 1983, p. 457-461.

Research output: Contribution to journalArticle

Jorizzo, JL, Apisarnthanarax, P, Subrt, P, Hebert, AA, Henry, JC, Raimer, S, Dinehart, SM & Reinarz, JA 1983, 'Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome', Archives of Internal Medicine, vol. 143, no. 3, pp. 457-461. https://doi.org/10.1001/archinte.143.3.457
Jorizzo, J. L. ; Apisarnthanarax, P. ; Subrt, P. ; Hebert, A. A. ; Henry, J. C. ; Raimer, Sharon ; Dinehart, S. M. ; Reinarz, J. A. / Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome. In: Archives of Internal Medicine. 1983 ; Vol. 143, No. 3. pp. 457-461.
@article{5e65387564cf4702af7fa66019288bda,
title = "Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome",
abstract = "A recurrent, episodic illness that occurs in as many as 20{\%} of patients who undergo ileojejunal bypass surgery for morbid obesity has been well characterized and includes inflammatory cutaneous lesions with a histologic appearance like that of neutrophillic vasculitis, a nondeforming polyarthritis, and other systemic manifestations. Current concepts of pathogenesis center on overgrowth of bacterial flora in the bypassed bowel segment with subsequent development of a circulating immune complex disease. We report, for the first time to our knowledge, an identical clinicopathologic syndrome in four patients who have not had jejunoileal bypass surgery. Each patient, however, had other gastrointestinal disease that we believe predisposed to this syndrome, possibly via circulating immune complexes with bowel-associated antigens. We propose the expanded term, bowel-associated dermatosis-arthritis syndrome, to incorporate these new cases. We believe that this is not a rare syndrome and that it is easily distinguishable from other types of cutaneous necrotizing vasculitis.",
author = "Jorizzo, {J. L.} and P. Apisarnthanarax and P. Subrt and Hebert, {A. A.} and Henry, {J. C.} and Sharon Raimer and Dinehart, {S. M.} and Reinarz, {J. A.}",
year = "1983",
doi = "10.1001/archinte.143.3.457",
language = "English (US)",
volume = "143",
pages = "457--461",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "3",

}

TY - JOUR

T1 - Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome

AU - Jorizzo, J. L.

AU - Apisarnthanarax, P.

AU - Subrt, P.

AU - Hebert, A. A.

AU - Henry, J. C.

AU - Raimer, Sharon

AU - Dinehart, S. M.

AU - Reinarz, J. A.

PY - 1983

Y1 - 1983

N2 - A recurrent, episodic illness that occurs in as many as 20% of patients who undergo ileojejunal bypass surgery for morbid obesity has been well characterized and includes inflammatory cutaneous lesions with a histologic appearance like that of neutrophillic vasculitis, a nondeforming polyarthritis, and other systemic manifestations. Current concepts of pathogenesis center on overgrowth of bacterial flora in the bypassed bowel segment with subsequent development of a circulating immune complex disease. We report, for the first time to our knowledge, an identical clinicopathologic syndrome in four patients who have not had jejunoileal bypass surgery. Each patient, however, had other gastrointestinal disease that we believe predisposed to this syndrome, possibly via circulating immune complexes with bowel-associated antigens. We propose the expanded term, bowel-associated dermatosis-arthritis syndrome, to incorporate these new cases. We believe that this is not a rare syndrome and that it is easily distinguishable from other types of cutaneous necrotizing vasculitis.

AB - A recurrent, episodic illness that occurs in as many as 20% of patients who undergo ileojejunal bypass surgery for morbid obesity has been well characterized and includes inflammatory cutaneous lesions with a histologic appearance like that of neutrophillic vasculitis, a nondeforming polyarthritis, and other systemic manifestations. Current concepts of pathogenesis center on overgrowth of bacterial flora in the bypassed bowel segment with subsequent development of a circulating immune complex disease. We report, for the first time to our knowledge, an identical clinicopathologic syndrome in four patients who have not had jejunoileal bypass surgery. Each patient, however, had other gastrointestinal disease that we believe predisposed to this syndrome, possibly via circulating immune complexes with bowel-associated antigens. We propose the expanded term, bowel-associated dermatosis-arthritis syndrome, to incorporate these new cases. We believe that this is not a rare syndrome and that it is easily distinguishable from other types of cutaneous necrotizing vasculitis.

UR - http://www.scopus.com/inward/record.url?scp=0020684980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020684980&partnerID=8YFLogxK

U2 - 10.1001/archinte.143.3.457

DO - 10.1001/archinte.143.3.457

M3 - Article

C2 - 6830382

VL - 143

SP - 457

EP - 461

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 3

ER -