Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis

Lucineia Gainski Danielski, Amanda Della Giustina, Marwa Badawy, Tatiana Barichello, João Quevedo, Felipe Dal-Pizzol, Fabrícia Petronilho

Research output: Contribution to journalReview articlepeer-review

138 Scopus citations

Abstract

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) are important for the maintenance of brain homeostasis. During sepsis, peripheral production of proinflammatory cytokines and reactive oxygen species are responsible for structural alterations in those brain barriers. Thus, an increasing permeability of these barriers can lead to the activation of glial cells such as microglia and the production of cytotoxic mediators which in turn act on the brain barriers, damaging them further. Thereby, in this review, we try to highlight how the brain barrier’s permeability is not only a cause but a consequence of brain injury in sepsis.

Original languageEnglish (US)
Pages (from-to)1045-1053
Number of pages9
JournalMolecular Neurobiology
Volume55
Issue number2
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

Keywords

  • Blood brain barrier
  • Blood-cerebrospinal fluid barrier
  • Microglial activation
  • Neuroinflammation
  • Sepsis

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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