TY - JOUR
T1 - Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis
AU - Danielski, Lucineia Gainski
AU - Giustina, Amanda Della
AU - Badawy, Marwa
AU - Barichello, Tatiana
AU - Quevedo, João
AU - Dal-Pizzol, Felipe
AU - Petronilho, Fabrícia
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) are important for the maintenance of brain homeostasis. During sepsis, peripheral production of proinflammatory cytokines and reactive oxygen species are responsible for structural alterations in those brain barriers. Thus, an increasing permeability of these barriers can lead to the activation of glial cells such as microglia and the production of cytotoxic mediators which in turn act on the brain barriers, damaging them further. Thereby, in this review, we try to highlight how the brain barrier’s permeability is not only a cause but a consequence of brain injury in sepsis.
AB - The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) are important for the maintenance of brain homeostasis. During sepsis, peripheral production of proinflammatory cytokines and reactive oxygen species are responsible for structural alterations in those brain barriers. Thus, an increasing permeability of these barriers can lead to the activation of glial cells such as microglia and the production of cytotoxic mediators which in turn act on the brain barriers, damaging them further. Thereby, in this review, we try to highlight how the brain barrier’s permeability is not only a cause but a consequence of brain injury in sepsis.
KW - Blood brain barrier
KW - Blood-cerebrospinal fluid barrier
KW - Microglial activation
KW - Neuroinflammation
KW - Sepsis
UR - http://www.scopus.com/inward/record.url?scp=85009433467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009433467&partnerID=8YFLogxK
U2 - 10.1007/s12035-016-0356-7
DO - 10.1007/s12035-016-0356-7
M3 - Review article
C2 - 28092082
AN - SCOPUS:85009433467
SN - 0893-7648
VL - 55
SP - 1045
EP - 1053
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 2
ER -