Brain microemboli during cardiac surgery or aortography

D. M. Moody, M. A. Bell, V. R. Challa, W. E. Johnston, Donald Prough

Research output: Contribution to journalArticle

309 Citations (Scopus)

Abstract

We have observed many focal dilatations or very small aneurysms in terminal arterioles and capillaries of 4 of 5 patients and 6 dogs who had recently undergone cardiopulmonary bypass. A smaller number of sausagelike dilatations distended medium-sized arterioles. Two other patients had a small number of the same microvascular changes following proximal aortography. Thirty-four patients and 6 dogs not undergoing cardiopulmonary bypass had none. (A 35th patient who had not undergone cardiopulmonary bypass or aortography showed a small number of dilatations; mediastinal air was a suggested source.) Some of the dilatations exhibited various forms of birefringence. Because most of the dilatations appear empty, we speculate that they are the sites of gas bubbles or fat emboli that have been removed by the solvents used in processing. These microvascular events, occurring only in conjunction with major arterial interventions, may be the anatomical correlate of the neurological deficits or moderate to severe intellectual dysfunction seen in at least 24% of patients after cardiac surgical procedures assisted by cardiopulmonary bypass.

Original languageEnglish (US)
Pages (from-to)477-486
Number of pages10
JournalAnnals of Neurology
Volume28
Issue number4
StatePublished - Oct 1990
Externally publishedYes

Fingerprint

Aortography
Thoracic Surgery
Dilatation
Cardiopulmonary Bypass
Brain
Arterioles
Cardiac Surgical Procedures
Dogs
Birefringence
Embolism
Aneurysm
Gases
Fats
Air

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Moody, D. M., Bell, M. A., Challa, V. R., Johnston, W. E., & Prough, D. (1990). Brain microemboli during cardiac surgery or aortography. Annals of Neurology, 28(4), 477-486.

Brain microemboli during cardiac surgery or aortography. / Moody, D. M.; Bell, M. A.; Challa, V. R.; Johnston, W. E.; Prough, Donald.

In: Annals of Neurology, Vol. 28, No. 4, 10.1990, p. 477-486.

Research output: Contribution to journalArticle

Moody, DM, Bell, MA, Challa, VR, Johnston, WE & Prough, D 1990, 'Brain microemboli during cardiac surgery or aortography', Annals of Neurology, vol. 28, no. 4, pp. 477-486.
Moody DM, Bell MA, Challa VR, Johnston WE, Prough D. Brain microemboli during cardiac surgery or aortography. Annals of Neurology. 1990 Oct;28(4):477-486.
Moody, D. M. ; Bell, M. A. ; Challa, V. R. ; Johnston, W. E. ; Prough, Donald. / Brain microemboli during cardiac surgery or aortography. In: Annals of Neurology. 1990 ; Vol. 28, No. 4. pp. 477-486.
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