Brain morphometric correlates of metabolic variables in HIV: the CHARTER study

S. L. Archibald, J. A. McCutchan, C. Sanders, T. Wolfson, T. L. Jernigan, R. J. Ellis, B. M. Ances, A. C. Collier, J. C. McArthur, S. Morgello, D. M. Simpson, C. Marra, Benjamin Gelman, D. B. Clifford, I. Grant, C. Fennema-Notestine

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Obesity and other metabolic variables are associated with abnormal brain structural volumes and cognitive dysfunction in HIV-uninfected populations. Since individuals with HIV infection on combined antiretroviral therapy (CART) often have systemic metabolic abnormalities and changes in brain morphology and function, we examined associations among brain volumes and metabolic factors in the multisite CNS HIV AntiRetroviral Therapy Effects Research (CHARTER) cohort, cross-sectional study of 222 HIV-infected individuals. Metabolic variables included body mass index (BMI), total blood cholesterol (C), low- and high-density lipoprotein C (LDL-C and HDL-C), blood pressure, random blood glucose, and diabetes. MRI measured volumes of cerebral white matter, abnormal white matter, cortical and subcortical gray matter, and ventricular and sulcal CSF. Multiple linear regression models allowed us to examine metabolic variables separately and in combination to predict each regional volume. Greater BMI was associated with smaller cortical gray and larger white matter volumes. Higher total cholesterol (C) levels were associated with smaller cortex volumes; higher LDL-C was associated with larger cerebral white matter volumes, while higher HDL-C levels were associated with larger sulci. Higher blood glucose levels and diabetes were associated with more abnormal white matter. Multiple atherogenic metabolic factors contribute to regional brain volumes in HIV-infected, CART-treated patients, reflecting associations similar to those found in HIV-uninfected individuals. These risk factors may accelerate cerebral atherosclerosis and consequent brain alterations and cognitive dysfunction.

Original languageEnglish (US)
Pages (from-to)603-611
Number of pages9
JournalJournal of NeuroVirology
Volume20
Issue number6
DOIs
StatePublished - Dec 12 2014

Fingerprint

HIV
Brain
Research
Blood Glucose
Linear Models
Body Mass Index
Cholesterol
Intracranial Arteriosclerosis
Therapeutics
Cohort Effect
HDL Lipoproteins
HIV Infections
Obesity
Cross-Sectional Studies
White Matter
Blood Pressure
Population
Cognitive Dysfunction
oxidized low density lipoprotein

Keywords

  • Cholesterol
  • HIV
  • Metabolic
  • Neuroimaging
  • Obesity

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

Archibald, S. L., McCutchan, J. A., Sanders, C., Wolfson, T., Jernigan, T. L., Ellis, R. J., ... Fennema-Notestine, C. (2014). Brain morphometric correlates of metabolic variables in HIV: the CHARTER study. Journal of NeuroVirology, 20(6), 603-611. https://doi.org/10.1007/s13365-014-0284-0

Brain morphometric correlates of metabolic variables in HIV : the CHARTER study. / Archibald, S. L.; McCutchan, J. A.; Sanders, C.; Wolfson, T.; Jernigan, T. L.; Ellis, R. J.; Ances, B. M.; Collier, A. C.; McArthur, J. C.; Morgello, S.; Simpson, D. M.; Marra, C.; Gelman, Benjamin; Clifford, D. B.; Grant, I.; Fennema-Notestine, C.

In: Journal of NeuroVirology, Vol. 20, No. 6, 12.12.2014, p. 603-611.

Research output: Contribution to journalArticle

Archibald, SL, McCutchan, JA, Sanders, C, Wolfson, T, Jernigan, TL, Ellis, RJ, Ances, BM, Collier, AC, McArthur, JC, Morgello, S, Simpson, DM, Marra, C, Gelman, B, Clifford, DB, Grant, I & Fennema-Notestine, C 2014, 'Brain morphometric correlates of metabolic variables in HIV: the CHARTER study', Journal of NeuroVirology, vol. 20, no. 6, pp. 603-611. https://doi.org/10.1007/s13365-014-0284-0
Archibald SL, McCutchan JA, Sanders C, Wolfson T, Jernigan TL, Ellis RJ et al. Brain morphometric correlates of metabolic variables in HIV: the CHARTER study. Journal of NeuroVirology. 2014 Dec 12;20(6):603-611. https://doi.org/10.1007/s13365-014-0284-0
Archibald, S. L. ; McCutchan, J. A. ; Sanders, C. ; Wolfson, T. ; Jernigan, T. L. ; Ellis, R. J. ; Ances, B. M. ; Collier, A. C. ; McArthur, J. C. ; Morgello, S. ; Simpson, D. M. ; Marra, C. ; Gelman, Benjamin ; Clifford, D. B. ; Grant, I. ; Fennema-Notestine, C. / Brain morphometric correlates of metabolic variables in HIV : the CHARTER study. In: Journal of NeuroVirology. 2014 ; Vol. 20, No. 6. pp. 603-611.
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