Abstract
Mouse animal models are widely used in experimental approaches to understand the pathology of
different disorders, including psychiatric, cognitive, neurodegenerative, and infectious diseases. The
brain from murine models is widely studied in the proteomics field presenting differences across
regions. However, the diversity in biophysical properties of native synaptic receptors across brain
regions remain elusive. Using mice synaptosomes from prefrontal cortex (PFx), hippocampus (H),
striatum (ST), olfactory bulb (OB), cerebellum (Cb), and medulla (Mdl) we investigate regional
differences of GABA, AMPA and glycine receptors sygnals, which are major drivers of synaptic
excitation (E) and inhibition (I) in the nervous system. Electrophysiological E/I ratios were assessed
by micro transplantation of synaptic membranes (MSM). Understanding the differences in the
functional status of synaptic receptors and their relationship with the synapto-proteome in different
mice brain areas is a necessary step to translate those differences to human research in different
neuropathological conditions.
different disorders, including psychiatric, cognitive, neurodegenerative, and infectious diseases. The
brain from murine models is widely studied in the proteomics field presenting differences across
regions. However, the diversity in biophysical properties of native synaptic receptors across brain
regions remain elusive. Using mice synaptosomes from prefrontal cortex (PFx), hippocampus (H),
striatum (ST), olfactory bulb (OB), cerebellum (Cb), and medulla (Mdl) we investigate regional
differences of GABA, AMPA and glycine receptors sygnals, which are major drivers of synaptic
excitation (E) and inhibition (I) in the nervous system. Electrophysiological E/I ratios were assessed
by micro transplantation of synaptic membranes (MSM). Understanding the differences in the
functional status of synaptic receptors and their relationship with the synapto-proteome in different
mice brain areas is a necessary step to translate those differences to human research in different
neuropathological conditions.
Original language | English (US) |
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State | Published - 2024 |
Event | UTMB GSBS Research Expo 2024 - Duration: Sep 20 2024 → Sep 20 2024 |
Exhibition
Exhibition | UTMB GSBS Research Expo 2024 |
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Period | 9/20/24 → 9/20/24 |