TY - JOUR
T1 - Brain serum amyloid P levels are reduced in individuals that lack Dementia while having Alzheimer's disease neuropathology
AU - Crawford, Jeffrey R.
AU - Gomer, Richard H.
AU - Bjorklund, Nicole L.
AU - Taglialatela, Giulio
PY - 2012/4
Y1 - 2012/4
N2 - The neuropathological signs of Alzheimer's disease (AD) include beta amyloid plaques and neurofibrillary tangles. There is a significant population of individuals that have these key hallmarks but show no signs of cognitive impairment, termed non-demented with AD neuropathology (NDAN). The protective mechanism allowing these individuals to escape dementia is unknown. Serum amyloid P (SAP) is a serum protein associated with wound repair that is elevated in the brains of Alzheimer's patients and binds to amyloid plaques. Using immunoblotting and immunohistochemistry, we evaluated SAP levels in postmortem samples of hippocampus and frontal cortex in age-matched controls, AD, and NDAN individuals. AD individuals had significantly increased SAP levels compared to normal controls, while NDAN samples had no significant difference in SAP levels compared to normal controls. Our results suggest that low levels of SAP in plaques marks the brains of individuals that escape dementia despite the presence of beta amyloid plaques and tangles.
AB - The neuropathological signs of Alzheimer's disease (AD) include beta amyloid plaques and neurofibrillary tangles. There is a significant population of individuals that have these key hallmarks but show no signs of cognitive impairment, termed non-demented with AD neuropathology (NDAN). The protective mechanism allowing these individuals to escape dementia is unknown. Serum amyloid P (SAP) is a serum protein associated with wound repair that is elevated in the brains of Alzheimer's patients and binds to amyloid plaques. Using immunoblotting and immunohistochemistry, we evaluated SAP levels in postmortem samples of hippocampus and frontal cortex in age-matched controls, AD, and NDAN individuals. AD individuals had significantly increased SAP levels compared to normal controls, while NDAN samples had no significant difference in SAP levels compared to normal controls. Our results suggest that low levels of SAP in plaques marks the brains of individuals that escape dementia despite the presence of beta amyloid plaques and tangles.
KW - Alzheimer's
KW - Betaamyloid plaque
KW - Hippocampus
KW - Neurofibrillary tangle
KW - Serum amyloid P
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U2 - 10.1007/s11064-011-0674-0
DO - 10.1007/s11064-011-0674-0
M3 - Article
C2 - 22205573
AN - SCOPUS:84860198467
SN - 0364-3190
VL - 37
SP - 795
EP - 801
JO - Neurochemical Research
JF - Neurochemical Research
IS - 4
ER -