@inproceedings{96063bed941b4d40ab0d50d57ba847e8,
title = "Brain tumor resection guided by fluorescence imaging and MRI image guidance",
abstract = "Recent evidence suggests a correlation between extent of tumor resection and patient prognosis, making maximal tumor resection a clinical ideal for neurosurgeons. Our group is currently undertaking a clinical study using fluorescence-based detection of tumor coupled with a standard 3-D image guidance system to study the effectiveness of fluorescence-based detection in the neurosurgical operating room. For fluorescence-based detection, we used 5-aminolevulinic acid to induce accumulation of protoporphyrin IX in malignant tissues. In this paper, we chose one prototypical, highly fluorescent case of glioblastoma multiforme, a high-grade glioma, to highlight some of the key findings and methodology used in our study of fluorescence-based detection and resection of brain tumors.",
keywords = "5-aminolevulinic acid, Fluorescence, Glioma resection, Image analysis, Protoporphyrin IX",
author = "Pablo Valdes and Harris, \{Brent T.\} and Frederic Leblond and Fontaine, \{Kathryn M.\} and Songbai Ji and Pogue, \{Brian W.\} and Alex Hartov and Roberts, \{David W.\} and Keith, \{Paulsen D.\}",
year = "2009",
doi = "10.1117/12.813868",
language = "English (US)",
isbn = "9780819475121",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Medical Imaging 2009",
note = "Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging ; Conference date: 08-02-2009 Through 10-02-2009",
}